Publications
1. Hsu, T., Wei, R., Dawson, M., and Karam, J.D. (1987) Identification of two bacteriophage T4 genes that may have roles in transcription and DNA replication. J. Virol. 61: 366-374.
2. Winter, R.B., Morrissey, L., Gold, L., Hsu, T., and Karam, J. (1987) The bacteriophage T4 regA protein binds to mRNAs and prevents translation initiation. Proc. Natl. Acad. Sci. (USA) 84: 7822-7826.
3. Liang, Y., Wei, R., Hsu, T., Alford, C., Dawson, M., and Karam, J. (1988) Autogenous regulation of the regA gene of bacteriophage T4: derepression of translation. Genetics 119: 739-749.
4. Andrake, M., Guild, N., Hsu, T., Gold, L., Tuerk, C., and Karam, J. (1988) The DNA polymerase of bacteriophage T4 is an autogenous translational repressor. Proc. Natl. Acad. Sci. (USA) 85: 7942-7946.
5. Hsu, T. and Karam, J. (1990) Transcriptional mapping of a phage T4 DNA replication gene cluster: sites for transcription initiation, transcription termination and mRNA processing. J. Biol. Chem. 265: 5303-5316.
6. Hsu, T., Gogos, J.A., Kirch, S.A., and Kafatos, F.C. (1992) Multiple zinc finger forms resulting from developmentally regulated alternative splicing of a transcription factor gene. Science 257: 1946-1950. [Highlighted in "This week in Science"]
7. Gogos, J.A., Hsu, T., Bolton, J., and Kafatos, F.C. (1992) Sequence discrimination by alternatively spliced isoforms of a DNA binding zinc finger domain. Science 257: 1951-1955. [Highlighted in "This week in Science"]
8. Hsu, T., King, D.L., LaBonne, C., and Kafatos, F.C. (1993) A Drosophila single-stranded DNA/RNA-binding factor contains a high-mobility-group box and is enriched in the nucleolus. Proc. Natl. Acad. Sci. (USA) 90: 6488-6492.
9. Hsu, T., Gogos, J.A., Bolton, J., and Kafatos, F.C. (1993) Alternatively spliced isoforms of a Cis2-His2 zinc-finger domain: developmental regulation and binding-site selection. Annals of The New York Academy of Sciences 684: 218-219.
10. Karam, J.D., Hsu, T., and Miller E.S. (1994) Large scale isolation of mRNA from T4-infected cells, in The Molecular Biology of Bacteriophage T4, Karam et al, eds., pp. 468-469. (American Society of Microbiology Press, Washington, D.C.)
11. Hsu, T. (corresponding author), Bagni, C., Sutherland, J.S., and Kafatos, F.C. (1996) The transcription factor CF2 is a mediator of EGF-R-activated dorsoventral patterning in Drosophila oogenesis. Genes & Development 10: 1411-1421. [Selected for Cover Photo].
12. Dobens, L.L., Hsu, T., Twombly, V., Gelbart, W.M., Raftery, L.A., and Kafatos, F.C. (1997) The Drosophila bunched gene is a homologue of the growth factor stimulated mammalian TSC-22 sequence and is required during oogenesis. Mech. Dev. 65:197-208.
13. Yeh, L.-S, Hsu, T., and Karam, J.D. (1998) Divergence of a DNA replication gene cluster in the T4-related bacteriophage RB69. J. Bacteriology 180: 2005-2013.
14. Mantrova, E.Y.? and Hsu, T. (1998) Down-regulation of transcription factor CF2 by Drosophila Ras/MAP kinase signaling in oogenesis: cytoplasmic retention and degradation. Genes & Development 12: 1166-1175.
15. Papenbrock, T., Peterson, R.L., Lee, R.S., Hsu, T., Kuroiwa, A., and Awgulewitsch, A. (1998) The murine Hoxc-9 gene contains a structurally and functionally conserved enhancer. Developmental Dynamics 212: 540-547.
16. Hsu, T. and Mantrova, E.Y.? (1999) Developmental specificity of the EGF receptor signaling: Feedback loops and novel regulatory mechanisms. Miami Nature Biotechnology Short Reports 10: 97.
17. Mantrova, E.Y.?, Schulz, R.A., and Hsu, T. (1999) Oogenic function of the myogenic factor D MEF2: negative regulation of the Dpp type I receptor thick veins. Proc. Natl. Acad. Sci. (USA) 96: 11889-11894.
18. Adryan, B.#, Decker, H.-J., Papas, T.S., and Hsu, T. (2000) Tracheal development and the von Hippel-Lindau tumor suppressor homolog in Drosophila. Oncogene 19: 2803-2811.
19. Hsu, T. (corresponding author) and Schulz, R.A. (2000) Sequence and functional properties of Ets genes in the model organism Drosophila. Oncogene 19: 6409-6416. [Review]
20. Hsu, T. (corresponding author), McRackan, D¶, Vincent, T.S. and de Couet, H.G. (2001) The Drosophila Pin1 prolyl isomerase Dodo is a MAP kinase signal responder during oogenesis. Nature Cell Biology 3: 538-543. [Accompanied by News and Views. Nature Cell Biology 3: E136-E137.]
21. Bagni, C., Bray, S., Gogos, J.A., Kafatos, F.C. and Hsu, T. (2002) The Drosophila zinc finger transcription factor CF2 is a myogenic marker downstream of MEF2 during muscle development. Mechanisms of Development 117: 265-268.
22. Dammai, V.? and Hsu, T. (2003) EGF-dependent and independent activation of MAP kinase during Drosophila oogenesis. Anatomical Record 272A: 377-382.
23. Lavenburg, K.R.?, Ivey, J.¶, Hsu. T. (co-corresponding author) and Muise-Helmericks, R. (2003) Coordinated functions of Akt and Ets1 in tubulogenesis. FASEB J. 17: 2278-2280 [Selected for cover photo].
24. Dammai, V.?, Adryan, B.#, Lavenburg, K.R.? and Hsu, T. (2003) Drosophila awd, the homolog of human nm23, regulates FGF receptor levels and functions synergistically with shi/dynamin during tracheal development. Genes & Dev. 17: 2812-2824.
25. Hsu, T., Trojanowska, M. and Watson, D.K. (2004) Ets proteins in biological control and cancer. J. Cell. Biochem. 91: 896-903. [Review]
26. Hsouna, A.?, Watson, D.K. and Hsu, T. (2004) Developmental expression patterns of D-ets4, the Drosophila homologue of human Pdef. Mech. Dev.-Gene Expr. Patterns 5: 285-289.
27. Cavaliere, V., Donati, A., Hsouna, A.?, Hsu, T. and Gargiulo, G. (2005) The dAkt kinase controls follicle cell size during Drosophila oogenesis. Developmental Dynamics 232: 845-854.
28. Adereth, Y.#, Champion, K. J.#, Hsu, T. and Vincent Dammai (2005) Site-directed mutagenesis using Pfu-DNA polymerase and T4-DNA ligase. BioTechniques 38: 864, 866, 868.
29. Pei, H., Li, C., Adereth, Y.#, Hsu, T., Watson, D.K. and Li, R. (2005) Caspase-1 is a direct target gene of ETS1 and plays a role in ETS1-induced apoptosis. Cancer Research 65: 7205-7213.
30. Adereth, Y.#, Dammai, V., Kose, N., Li, R. and Hsu, T. (2005) RNA-dependent integrin 3 protein localisation regulated by the Muscleblind-like protein MLP1. Nature Cell Biology 7: 1240-1247 [Accompanied by News and Views Nature Cell Biology 7: 1155-1156] [Highlighted in Nature Cell Migration Gateway, Dec. 2005]
31. Arquier, N., Vigne, P., Duplan, E., Hsu, T., Therond, P.P., Frelin, C. and D'Angelo, G. (2006) Analysis of the hypoxia-sensing pathway in Drosophila melanogaster. Biochem. J., 393: 471-480.
32. Hsu, T. (co-corresponding author), Adereth, Y.?, Kose, N. and Dammai, V. (2006) Endocytic function of Von Hippel-Lindau tumor suppressor protein regulates surface localization of FGF receptor 1 and cell motility. J. Biol. Chem. 281: 12069-12080. [Editor's Choice, Cancer, Science's STKE, May 2006]
33. Hsouna, A.?, Lawal, H.O., Izevbaye, I. and Hsu, T. (co-corresponding author) and O'Donnell, J.M. (2007) Drosophila dopamine synthesis pathway genes regulate tracheal morphogenesis. Dev. Biol. 308: 30-43.
34. Nallamothu, G.?, Woolworth, J.A.#, Dammai, V. and Hsu, T. (2008) awd, the homolog of metastasis suppressor gene Nm23, regulates Drosophila epithelial cell invasion. Mol. Cell. Biol. 28: 1964–1973.
35. Chintalapudi, M. R.?, Markiewicz, M., Kose, N, Dammai, V., Championl, K.J.#, Hoda, R. S., Trojanowska, M. and Hsu, T. (2008) Cyr61/CCN1 and CTGF/CCN2 mediate the pro-angiogenic activity of VHL mutant renal carcinoma cells. Carcinogenesis 29: 696-703.
36. Champion, K.J.#, Guinea, M.?, Dammai, V. and Hsu, T. (2008) Endothelial function of von Hippel-Lindau tumor suppressor gene: control of FGF receptor signaling. Cancer Research 68: 4649-4657. [IF: 12.7; 16/211, Cancer Research]
37. Bu, S., Kapanadze, B., Hsu, T. and Trojanowska, M. (2008) Opposite effects of dihydrosphingosine 1-phosphate and sphingosine 1-phosphate on TGFbeta/Smad pathway are mediated through the PTEN/PPM1A dependent pathway. J. Biol. Chem. 283:19593-19602.
38. Mahajan, S., Dammai, V., Hsu. T. and Kraft, A.S. (2008) Hypoxia-inducible factor-2alpha regulates the expression of TRAIL receptor DR5 in renal cancer cells. Carcinogenesis 29: 1734-1741.
39. Nallamothu, G.?, Dammai, V. and Hsu, T. (2009) Developmental Function of Nm23/awd - A Mediator of Endocytosis. Mol. Cell. Biochm. 329: 35-44. [Review]
40. Woolworth, J.A.#, Nallamothu, G.•, and Hsu, T. (2009) The Drosophila metastasis suppressor Nm23 homolog, awd, regulates epithelial integrity during oogenesis. Mol. Cell. Biol. 29: 4679-4690. [Selected for cover photo]
41. Duchi, S.#, Fagnocchi, L., Cavaliere, V., Hsouna, A.?, Gargiulo, G. and Hsu, T. (2010) Drosophila VHL tumor suppressor gene regulates epithelial morphogenesis by promoting microtubule stability. Development 137:1493-1503. [Featured "In This Issue"]
42. Hsouna, A.•, Kose, N., Guinea, M.?, Dammai, V. and Hsu, T. (2010) Drosophila von Hippel-Lindau tumor suppressor gene regulates epithelial tubule migration and lumen formation by promoting endocytosis. Mol. Cell. Biol. 30:3779-3794. [Featured in "Spotlight"][Selected for cover photo]
43. Hsu, T. (2011) NME Genes in Epithelial Morphogenesis. Naunyn-Schmiedeberg Arch. Pharm. 384: 363-372. [Review]
44. Liby, T.A., Spyropoulos, P., Lindner, H.B., Eldridge, J., Beeson, C., Hsu, T. and Muise-Helmericks, R.C. (2012) Akt3 Controls VEGF secretion and angiogenesis in ovarian cancer cells. Int. J. Cancer. 130: 532-543.
45. Hsu, T. (2012) Complex cellular functions of the von Hippel-Lindau tumor suppressor gene: Insights from model organisms. Oncogene 31: 2247-2257. [Invited Review]
46. Bader, H. L.? and Hsu, T. (2012) Systemic VHL gene functions and the VHL disease. FEBS Lett. 586:1562-1569. [Invited Review]
47. Bader, H. L.•, Pritchett, T.L.?, and Hsu, T. (2012) Hematopoietic Functions of the Tumor Suppressor Von Hippel Lindau (VHL) in the Etiology of Hemangioblastoma. Blood 120: 2425-2425.
48. Ignesti, M., Barraco, M., Nallamothu, G.•, Woolworth, J.A.#, Duchi, S., Gargiulo, G., Cavaliere, V. and Hsu, T. (2014) Notch signaling during development requires the function of awd, the Drosophila homolog of human metastasis suppressor gene Nm23. BMC Biology. 12:12. [IF: 6.97; 31/204, Biochemistry, Genetics, and Molecular Biology]
49. Lin, C.H.#, Dammai, V. Adryan, B. and Hsu, T. (2015) Interaction between Nm23 and the tumor supressor VHL. Naunyn-Schmiedeberg Arch. Pharm. 388: 143-152. [IF: 2.38; 204/773, Pharmacology]
50. Pritchett, T.L.•, Bader, H.L.•, Henderson, J. and Hsu, T. (2015) Conditional inactivation of the mouse von Hippel–Lindau tumor suppressor gene results in wide-spread hyperplastic, inflammatory, and fibrotic lesions in the kidney. Oncogene, 34: 2631-2639. [IF: 8.56; 19/196, Oncology]
51. Hsu, T., Steeg, P. S., Zollo, M. and Wieland, T (2015) Progress on Nme (NDP kinase/Nm23/Awd) gene family-related functions derived from animal model systems: studies on development, cardiovascular disease, and cancer metastasis exemplified (Editorial) Naunyn-Schmiedeberg Arch. Pharm. 388: 109-117. [IF: 2.38; 204/773, Pharmacology]
52. Kirschner, R, Hsu, T., Tuan, N.N., Chen, C.L. and Huang, S.L. (2015) Characterization of Fungal and Bacterial Components in Gut/Fecal Microbiome. Curr. Drug Metab. 16: 272-283. [IF: 2.98; 82/254 Pharmacology]
53. Romani, P., Papi, A., Ignesti, M., Soccolini, G., Hsu, T., Gargiulo, G., Spisni, E., and Cavaliere, V. (2016) Dynamin controls extracellular level of Awd/Nme1 metastasis suppressor protein. Naunyn-Schmiedeberg Arch. Pharm. 389: 1171-1182. [IF: 2.38; 204/773, Pharmacology]
54. Bader, H.L.? and Hsu, T. (2016) Inactivation of the tumor suppressor gene von Hippel-Lindau (VHL) in granulocytes contributes to development of liver hemangiomas in a mouse model. BMC Cancer. 16: 797. [IF: 3.36; 63/322, Oncology]
55. Kuo, C.Y.,• Lin, C.H.,# and Hsu, T. (2017) VHL inactivation in precancerous kidney cells induces an inflammatory response via ER stress-activated IRE1α signaling. Cancer Research. 77: 3406-3416. [9.12; 9/344, Oncology] [This paper won the Ministry of Science and Technology, Taiwan, Outstanding Postdoctoral Research Paper Award, 2017].
56. Huang, H.-Y., Hsu, T. and Lin, B.F. (2017) gamma-Aminobutyric acid alleviates progression of renal inflammation and injury in the Vhlh gene-knockout mice: Tu-P14-28. Cytokine. 100: 185-186. [IF: 3.08; 107/446, Biochemistry]
57. Romani, P., Ignesti, M., Gargiulo, G., Hsu, T. (co-corresponding), and Cavaliere, V. (2018) Extracellular NME proteins: a player or a bystander? Lab. Invest. 98:248-257. [IF: 4.86; 16/128 Medicine, Research and Experimental]
58. Chen, H.Y., Hsiao, Y.T., Liu, S.C.,• Hsu, T., Woon, W.Y., and I, L. (2018) Enhancing Cancer Cell Collective Motion and Speeding up Confluent Endothelial Dynamics through Cancer Cell Invasion and Aggregation. Physical Rev. Lett. 121:018101. [IF: 8.84; 7/268, Physics and Astronomy]
59. Liu, S.C., Hsu, T., Chang, Y.S., Chung, A.K., Jiang, S.S, OuYang, C.N., Hsueh, C., Liu, Y.P., Yuh, C.H., and Tsang, N.M. (2018) Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through YAP1-FAK/PXN signaling. Nature Communications. 9: 5105. [IF: 12.35; 3/64, Multidisciplinary Sciences]
60. Huang, H.-Y., Hsu, T., and Lin, B.F. (2019) Gamma-aminobutyric acid decreases macrophages infiltration and suppresses inflammatory responses in renal injury. J. Functional Food. 60: 103419. [IF: 3.78; 37/206; Medicine (miscellaneous)]
61. Mezzofanti, E., Ignesti, M., Hsu, T., Gargiulo, G., and Cavaliere, V. (2019) Vps28 is involved in the intracellular trafficking of Awd, the Drosophila homologue of NME1/2. Frontiers Physiol. 10: 983. [IF: 4.13; 47/167, Physiology]
62. Tseng, C.-H., Lin, C., Chang, H.-C., Liu, C.-C., Serafico, B.M.F., Wu, L.-C., Lin, C.-T., Hsu, T., Huang, C.-Y., and Lo, M.-T. (2019) A Real-World Implementation of Cloud-Based AI System for Large-Scale Arrhythmia Screening. IEEE Computer. 52: 40-51. [IF: 3.56; 12/107; Computer Science, software engineering]
63. Hsu, T., Nguyen-Tran, Hieu-Huy #, and Trojanowska, M.E. (2019) Active roles of dysfunctional vascular endothelium in fibrosis and cancer. J. Biomed. Sci. 26: 86. [Invited review] [IF: 5.20; 80/277, Cancer Research]
64. Nguyen-Tran, H.-H.# and Hsu, T. (2020) Endothelial cell activation in the conditional Vhlh knockout kidney through oncostatin M pathway. Cancer Immunol. Res. (3 Supplement) A99-A99.
65. Nguyen, T.-N.# and Hsu, T. (2020) VHL inactivated kidney epithelial cells reprogram macrophage behavior through IL-6 and CXCL-1 secretion. Cancer Immunol. Res. (3 Supplement) B92-B92.
66. Chen, C.-Y., Lee, D.S., Choong, O.K., Chang, S.-K., Hsu, T., Nicholson, M.W., Liu, L.-W., Lin, P.-J., Ruan, S.-C., Lin, S.-W., Hu, C.-Y. and Hsieh, P.C.H. (2021) Cardiac-specific MicroRNA-125b deficiency induces perinatal death and cardiac hypertrophy. Sci. Rep. 11:2377. [IF: 4.149; 10/135, Multidisciplinary 10/135]
67. Pan, S.-Y., Tsai, P.-Z., Chou, Y.-H., Chang, Y.-T., Chang, F.-C., Chiu, Y.-L., Chiang, W.-C., Hsu, T., Wu, M.-., Chen, Y.-M., Chu, T.-S., and Lin, S.-L. (2021) Kidney pericyte hypoxia-inducible factor regulates erythropoiesis but not kidney fibrosis. Kidney International 99: 1354–1368. [IF: 8.945; 3/66 Medicine-Nephrology]
68. Nguyen-Tran, H.-H., # Nguyen, T.-N., # Chen, C.-Y. ? and Hsu, T. (2021). Endothelial reprograming stimulated by oncostatin M promotes inflammation and tumorigenesis in VHL-deficient kidney tissue. Cancer Res. 81: 5060-5073. [IF: 12.7; 16/211, Cancer Research] 69. Kuo, C.Y., Chiu, V., Hsieh, P.C., Hsu, T. and Lin, T.-Y. (2021) Loss of function of von Hippel-Lindau triggers lipocalin 2-dependent inflammatory responses in cultured and primary renal tubular cells. Oxidative Medicine and Cellular Longevity 2021: 5571638. [IF: 5.076; 10/35, Aging]