基本資料/Profiles

Dr. 張瓊文(Mary Chang)實驗室致力於利用生物化學，生物物理及結構生物學技術 (x-ray蛋白晶體繞射及冷凍電子顯微鏡)，來探討並解析蛋白質特質及3D立體結構。同時亦積極從事轉譯醫學研究，尋找治療癌症或感染性疾病的標靶，·並開發設計專一性藥物，希望未來能夠對病患有所助益。 目前研究的主題為探討細胞間的溝通途徑及方式。尤其是跟病理相關的細胞，如癌細胞、免疫細胞及致病性微生物細胞(microbiome) 包括: 細菌、黴菌及病毒。我們也積極與癌症及微生物研究團隊建立合作關係，來加深對研究主題的了解並進一步發展相關治療策略。 Dr. Mary Chang’s lab is dedicated to the functional and structural studies of biologically essential proteins in fundamental biology. By employing integrative tools, including X-ray crystallography, Cryo-EM, biophysical, biochemical, and cellular based methods, the lab determines and dissects the 3D protein structures to address how the protein functions and interacts with its binding partners, such as small compounds and proteins. Her research aims to combine basic and translational research to uncover potential therapeutic targets for treating cancer and infectious diseases. By developing small compounds or antibody drugs with her collaborators, she hopes to provide effective cures that are helpful for patients.

醫學院生物化學暨分子生物研究所 助理教授／Institute of Biochemistry and Molecular Biology Assistant Professor

基本資料/Profiles

學歷/Education

  • The University of Queensland, Brisbane, Australia. Ph.D. in Biochemistry and Molecular Biology
  • Graduate Diploma of Biotechnology. The Queensland University of Technology, Brisbane, Australia
  • Master of International Business The Queensland University of Technology, Brisbane, Australia

經歷/Work experience

  • Assistant Professor Institute of Biochemistry and Molecular Biology, China Medical University, Taichung, Taiwan(1130105~)
  • Taiwan Protein Project manager Institute of Biological Chemistry, Academia Sinica, Taiwan(1080305~1121231)
    (Advisor: Dr. Ming-Daw Tsai)
  • Post-Doctoral Research MD Anderson Cancer Center, UT, Houston, U.S.(1070101~1080228)
    (Advisor: Dr. Mien-Chie Hung/Dr. Zhao Wang)
  • Post-Doctoral Research Baylor College of Medicine, Houston, Texas, U.S.(1040401~1061231)
    (Advisor: Dr. Francis Tsai)
  • Post-Doctoral Research The University of Queensland, Brisbane, Australia(1030201~1031231)
    (Advisor: Dr. Bo?tjan Kobe)
  • Research Assistant The Graduate School of Microbiology & Immunology, National Defense Medical Center, Taiwan.(0930801~0940831)
    (Advisor: Dr. S. -Y. Jiang)
  • Master Research The Graduate School of Biochemistry, National Defense Medical Center, Taiwan(0910901~0930630)
    (Advisor: Dr. H. -J. Lee)
  • Research Assistant The Graduate School of Pharmaceutical Chemistry, China Medical University, Taiwan(0900701~0910131)
    (Advisor: Dr. C. -H. Wu)

主管經歷/Administrative experience

專長/Research expertise

  • 生物化學 / Biochemistry
  • 蛋白質結構生物學 / Structural Biology
  • X-ray 蛋白晶體結構學 / X-ray macromolecular crystallography
  • 單顆粒冷凍電子顯微鏡 / Single Particle Cryo-genic electron microscopy