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我的研究主題是針灸鎮痛和抗憂鬱的機制。我們希望探究針灸作用的潛在機制。我們擁有多種方法來識別針灸治療的新機制，例如免疫螢光標記/示踪、電生理學、三光纖光度計、行為學檢查和化學遺傳學技術。我們發現，針灸可以減輕多種疼痛模型（發炎性疼痛、纖維肌痛、神經性疼痛）誘發的機械性和熱性痛覺過敏。我們也發現，針灸可能透過電生理方法降低背根神經節神經元中的傷害性鈉電流。在這些疼痛模型中，TRPV1及其相關的疼痛訊號路徑活性增強，而針灸可以進一步抑制這些路徑。在TRPV1基因敲除小鼠中，TRPV1及其相關訊號路徑的活性受到抑制，這表明TRPV1基因敲除小鼠對多種疼痛模型具有抵抗力。此外，上述機制也存在於憂鬱小鼠。透過我們的研究，我們加深了對針灸可能透過調節TRPV1及其相關訊號路徑來減輕痛覺過敏的機制的理解。 I am a professor from graduate institute of acupuncture science at the China Medical University. My primary research interest is acupuncture science. My research topic is concerning about the mechanisms of acupuncture analgesia and depression. We want to investigate the mechanisms underlying antinociceptive effect of acupuncture. We recently published a clinical trial paper to show that acupuncture effectively reduced CPDC. We have several methods to identify novel mechanisms in acupuncture therapy such as immunofluoroscence labeling/tracing, electrophysiology, miniscopes, behavioral examinations and chemogenetic techniques. We suggest that several pain (inflammatory, fibromyalgia, neuropathic) models-induced mechanical and thermal hyperalgesia was attenuated by acupuncture. We also indicate that acupuncture may also reduce nociceptive sodium currents, via electrophysiology, in dorsal root ganglion neurons. TRPV1 and associated pain signaling pathways was increased in these pain models and further attenuated by acupuncture. TRPV1 and associated signaling pathways can be prevented in TRPV1 knockout mice, suggesting that TRPV1 knockout mice are resistant to several pain model. In addition, aforementioned mechanisms were also found in depressive mice. Through our study, we have increased the understanding of the mechanism that acupuncture might alter TRPV1 and associated signaling pathways to reduce hyperalgesia. We aim to use novel aforementioned methods to clarify detail mechanisms at neuronal circuit level. At the same time, clinical trials will have confirmed the efficacy and mechanisms of acupuncture. We hope these findings could be applied in clinical medicine for better therapy and reduced medical costs. ORCID: Google Scholar Scopus Web of Science（WOS）

中醫學院針灸研究所教授／Graduate Institute of Acupuncture Science Professor

基本資料/Profiles

姓名：林以文／Lin, Yi-Wen
任職單位：中醫學院針灸研究所教授
Graduate Institute of Acupuncture Science Professor
電話：(04)22053366 分機
E-mail：yiwenlin@mail.cmu.edu.tw
ORCID：https://orcid.org/0000-0001-7204-8837
Google Scholar個人學術檔案

學歷/Education

陽明大學生理博士
National Yang-Ming University PhD
中國醫藥大學基礎醫學碩士
China Medical University Master
中國醫藥學院醫技系學士
China Medical University Bachelor

經歷/Work experience

中國醫藥大學中醫學院針灸研究所助理教授(0980201~1010131)
China Medical University Graduate Institute of Acupuncture Science Assistant Professor
中國醫藥大學中醫學院針灸研究所副教授(1010201~1050731)
China Medical University Graduate Institute of Acupuncture Science Associate Professor
中國醫藥大學中醫學院學士後中醫學系教授(1050801~1060131)
中國醫藥大學中醫學院針灸研究所教授(1060201~)

主管經歷/Administrative experience

研究發展處行政組組長(1120220~1140731)
Administration Division Chief
中醫暨針灸研究中心副主任(1050901~1060731)
Acupuncture Research Center Vice Chairman

專長/Research expertise