John S. Kuo MD PhD (Principal Investigator) leads the Brain Tumor / Neuroengineering Research Group which focuses on developing novel therapies for primary and metastatic brain tumors. Currently, we are pursuing research to improve outcomes for patients with glioblastoma (GBM), a highly aggressive and malignant brain cancer associated with less than 2 years survival after diagnosis. We isolate and study therapeutically resistant GBM cancer stem cells (GSC) hypothesized to drive cancer growth and recurrence after current therapies. We develop and use many techniques to understand and study the molecular biology of GSC and elucidate clinically relevant biomarkers by comparison studies on normal brain cells and brain stem cells. We also use animal tumor models and clinically annotated tumor tissue microarrays to test and validate new cancer targeting agents and experimental therapeutics. From our studies, we aim to develop CSC-targeted therapies to synergize and enhance current brain tumor treatments, ultimately improving outcomes for cancer patients. We are also pursuing new projects to advance the treatment of cancers that metastasize to the brain, using immunotherapy and new cancer targeting strategies. For more information and current CV, please visit our lab web site: https://kuolab.cmu.edu.tw/

醫學院生物醫學研究所 講座教授/Graduate Institute of Biomedical Sciences Chair Professor



  • 麻省理工學院 生物博士
    MIT, PhD
  • 哈佛大學醫學院 醫學博士
    Harvard Medical School, MD
  • 哈佛大學 生物學士(最高榮譽)
    Harvard University, AB summa cum laude

經歷/Work experience

  • 中國醫藥大學 生物醫學研究所 講座教授(1100901~)
    China Medical University Graduate Institute of Biomedical Sciences Chair Professor
  • 亞洲大學 生物資訊與醫學工程學系 講座教授(1101001~)
  • 玉山學者(1100901~)
  • 美國德州大學奧斯汀分校 Dell醫學院 神經外科系 創辦系主任(1070401~1100831)
    Inaugural (Founding) Department Chair, Department of Neurosurgery, Dell Medical School, The University of Texas at Austin, Austin, TX, USA
  • 美國德州大學奧斯汀分校 Mulva神經科醫院 外科主任(1070401~1100831)
    Surgical Director, Mulva Clinic for the Neurosciences, The University of Texas at Austin, Austin, TX, USA
  • Dept. of Neurosurgery, Dell Medical School, Univ. of Texas at Austin, Tenured Professor(1070416~1100831)
  • Neurological Surgery & Human Oncology, Univ. of Wisconsin-Madison, Tenured Professor(1060701~1070415)
  • Neurological Surgery & Human Oncology, Univ. of Wisconsin-Madison, Tenured Associate Professor(1020701~1060630)
  • Neurological Surgery, Univ. of Wisconsin-Madison, Assistant Professor(0941001~1020630)

主管經歷/Administrative experience

  • 校長室副校長(1100901~1130731)
    Office of the President Vice President
  • 雙語教學推動資源中心主任(1101101~1130731)
  • 神經醫學中心中心主任(1120801~1130731)
  • 神經醫學中心中心主任(1110201~1120731)

專長/Research expertise

  • 腦腫瘤神經外科, 癌症幹細胞生物學 / Neurosurgical oncology, cancer stem cell biology
  • 癌症實驗療法, 立體定向放射治療, 腦垂體瘤 / Experimental therapeutics, stereotactic radiosurgery, pituitary tumors
  • 分子,轉譯和臨床癌症和腦神經醫學科學研究 / molecular, translational and clinical research for cancer and neuroscience