學術研究成果/Publication
基本資料/Profiles
姓名/Name: 李家琳 性別/Gender:
英文姓名/
English Name:
Lee, Chia-Lin 英文縮寫/
Abbreviation:
CL Lee
任職單位/
Affiliation:
1.生技製藥暨食品科學院藥用化妝品學系(副教授) / Department of Cosmeceutics(Associate Professor)
2.中國附醫中醫藥研究發展中心(博士後研究員) / China Medicine R&D Center(Post-Doctoral Fellow)
Email: chlilee@mail.cmu.edu.tw
研究專長/Fields of Specialty
1﹒ 天然物化學
2﹒ 藥物化學
3﹒ 新藥開發
4﹒ 中草藥
5﹒ New drug development of Chinese medicines
6﹒ Natural products chemistry
7﹒ NMR
8﹒ MS
 
期刊論文/Journal Paper
(作者群,論文題目,期刊名稱,出版年月,卷號(期別):頁次起迄)
SCI論文 李家琳(Chia-Lin Lee)、楊顓丞、(Chieh-Yu Peng)、吳永昌(Yang-Chang Wu)*,Saponins from Solanum torvum and S. macaonense with Their Cytotoxic and Anti-allergic Effects,Natural Product Communications,2017 ,():
SCI論文 李家琳(Chia-Lin Lee)、李守倫(Lee, Shou-Lun)、陳朝榮(Chao-Jung Chen)、陳信君(HSIN-CHUN CHEN)、高銘欽(Ming-Ching Kao)、(Chuan-Hao Liu)、(Jau-Yang Chen)、(Yen-Ting Lai)、吳永昌(Yang-Chang Wu)*,Characterization of secondary metabolites from purple Ipomoea batatas leaves and their effects on glucose uptake,MOLECULES,2016 Jun,21():745
SCI論文 (Chieh Yu Peng)、游邦照(Bang-Jau You)、李家琳(Chia-Lin Lee)、吳永昌(Yang-Chang Wu)、林文鑫(Wen-Hsin Lin)、陸德齡(Lu Te-Ling)、(Fei-Ching Chang)、李鳳琴(Hong-Zin Lee)*,The roles of 4β-hydroxywithanolide E from Physalis peruviana on the Nrf2-antioxidant system and cell cycle in breast cancer cells,AMERICAN JOURNAL OF CHINESE MEDICINE,2016 May,44(3):1-20
SCI論文 (Ching-Peng Chiu)、(Shan-Chi Liu)、(Chih-Hsin Tang)、(You Chan)、(Mohamed EI-Shazly)、李家琳(Chia-Lin Lee)、(Ying-Chi Du)、吳東穎(Tung-Ying Wu)、(Fang-Rong Chang)*、吳永昌(Yang-Chang Wu)*,Anti-inflammatory cerebrosides from cultivated Cordyceps militaris,JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2016 Feb,64():1540-1548
SCI論文 (Ching-Chia Li)、楊顓丞、(Mei-Chin Lu)、李家琳(Chia-Lin Lee)、(Chieh-Yu Peng)、(Wei-Yu Hsu)、(Yun-Hao Dai)、(Fang-Rong Chang)、(Da-Yong Zhang)、(Wen-Jeng Wu)*、吳永昌(Yang-Chang Wu)*,ATR-Chk1 signaling inhibition as a therapeutic strategy to enhance cisplatin chemosensitivity in urothelial bladder cancer,Oncotarget,2016 Jan,7(2):1947-1959
SCI論文 廖容君(Jung-Chun Liao)、(Kun-Tsung Lee)、游邦照(Bang-Jau You)、李家琳(Chia-Lin Lee)、張文德(Wen-Te Chang)、吳永昌(Yang-Chang Wu)、李鳳琴(Hong-Zin Lee)*,Raf/ERK/Nrf2 Signaling Pathway and MMP-7 Expression Involvement in the Trigonelline-mediated Inhibition of Hepatocarcinoma Cell Migration,Food & Nutrition Research,2015 Dec,59():29884
SCI論文 李家琳(Chia-Lin Lee)*、(Ming-Hon Yen)、(Tsong-Long Hwang)、楊顓丞、彭婕妤(Chieh-Yu Peng)、陳朝榮(Chao-Jung Chen)、(Wen-Yi Chang)、吳永昌(Yang-Chang Wu),Anti-inflammatory and cytotoxic components from Dichrocephala integrifolia,Phytochemistry Letters,2015 May,12():237-242
SCI論文 李家琳(Chia-Lin Lee)、(Tsong-Long Hwang)、彭婕妤(Chieh-Yu Peng)、陳朝榮(Chao-Jung Chen)、郭昭麟(Kuo Chao-Lin)、(Wen-Yi Chang)、吳永昌(Yang-Chang Wu)*,Anti-inflammatory and cytotoxic compounds from Solanum macaonense,Natural Product Communications,2015 Feb,10(2):345-348
SCI論文 (Chieh-Yu Liao)、李家琳(Chia-Lin Lee)、(Hui-Chun Wang)、(Shih-Shin Liang)、(Po-Hsiung Kung)、吳永昌(Yang-Chang Wu)、(Fang-Rong Chang)、(Chin-Chung Wu)*,CLL2-1, a chemical derivative of orchid 1,4-phenanthrenequinones, inhibits human platelet aggregation through thiol modification of calcium-diacylglycerol guanine nucleotide exchange factor-I (CalDAG-GEFI),FREE RADICAL BIOLOGY AND MEDICINE,2015 Jan,78():101-110
SCI論文 李家琳(Chia-Lin Lee)、(Tsong-Long Hwang)、楊顓丞、(Hao-Ting Cheng)、何宛融、(Chiao-Ting Yen)、郭昭麟(Kuo Chao-Lin)、陳朝榮(Chao-Jung Chen)、(Wen-Yi Chang)、吳永昌(Yang-Chang Wu)*,Anti-inflammatory spirostanol and furostanol saponins from Solanum macaonense,JOURNAL OF NATURAL PRODUCTS,2014 Jul,77(-):1770-1783
SCI論文 游邦照(Bang-Jau You)、吳永昌(Yang-Chang Wu)、李家琳(Chia-Lin Lee)、李鳳琴(Hong-Zin Lee)*,Non-homologous end joining pathway is the major route of protection against 4b-hydroxywithanolide E-induced DNA damage in MCF-7 cells,FOOD AND CHEMICAL TOXICOLOGY,2014 Mar,65(-):205-212
SCI論文 李家琳(Chia-Lin Lee)、(Ming-Hon Yen)、(Fang-Rong Chang)、(Chin-Chung Wu)、吳永昌(Yang-Chang Wu)*,Antiplatelet Aggregation Effects of Phenanthrenes from Calanthe arisanensis,Natural Product Communications,2014 Jan,9(1):83-84
SCI論文 李家琳(Chia-Lin Lee)、(Tsong-Long Hwang)、何宛融、(Yi-Hong Tsai)、(Chiao-Ting Yen)、(Hsin-Fu Yen)、陳朝榮(Chao-Jung Chen)、(Wei-Yi Chang)、吳永昌(Yang-Chang Wu)*,Anti-neutrophilic inflammatory steroidal glycosides from Solanum torvum,PHYTOCHEMISTRY,2013 Jul,95():315-321
SCI論文 李家琳(Chia-Lin Lee)、(Tsong-Long Hwang)、彭婕妤(Chieh-Yu Peng)、陳朝榮(Chao-Jung Chen)、張永勳(Yuan Shiun Chang)、吳永昌(Yang-Chang Wu)*,Anti-neutrophilic inflammatory secondary metabolites from the traditional Chinese medicine, Tiankuizi,Natural Product Communications,2012 Dec,7(12):1623-1626
SCI論文 李家琳(Chia-Lin Lee)、(Ying-Ting Lin)、(Fang-Rong Chang)*、陳冠宇(Guan-Yu Chen)、(Anders Backlund)、(Juan-Chang Yang)、(Shu-Li Chen)、吳永昌(Yang-Chang Wu)*,Synthesis and Biological Evaluation of Phenanthrenes as Cytotoxic Agents with Pharmacophore Modeling and ChemGPS-NP Prediction as Topo II Inhibitors,PLoS One,2012 May,7(5):37897-37897
SCI論文 (Yu-Chi Tsai)、(Wan-Chun Lai)、(Ying-Chi Du)、(Shou-Fang Wu)、(Mohamed El-Shazly)、李家琳(Chia-Lin Lee)、(Ming-Hong Yen)、(Ming-Feng Hou)、吳永昌(Yang-Chang Wu)、(Fang-Rong Chang)*,Lignan and Flavonoid Phytoestrogens from the Seeds of Cuscuta chinensis,JOURNAL OF NATURAL PRODUCTS,2012 May,():
SCI論文 (Chiao-Ting Yen)、李家琳(Chia-Lin Lee)、(Fang-Rong Chang)、(Tsong-Long Hwang)、(Hsin-Fu Yen)、陳朝榮(Chao-Jung Chen)、(Shu-Li Chen)、吳永昌(Yang-Chang Wu)*,Indiosides G-K: steroidal glycosides with cytotoxic and anti-inflammatory activities form Solanum violaceum,JOURNAL OF NATURAL PRODUCTS,2012 ,75(4):636-643
SCI論文 (Yu-Ming Chung)、(Hui-Chun Wang)、(Mohamed El-Shazly)、(Yann-Lii Leu)、(Ming-Ching Cheng)、李家琳(Chia-Lin Lee)、(Fang-Rong Chang)、吳永昌*,Antioxidant and tyrosinase inhibitory constituents from the desugared sugarcane extract, a by-product of sugar production,JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2011 Sep,59(17):9219-9225
SCI論文 (Juan-Cheng Yang)、(Mei-Chin Lu)、李家琳(Chia-Lin Lee)、陳冠宇(Guan-Yu Chen)、(Yan-Yu Lin)、(Fang-Rong Chang)*、吳永昌*,Selective targeting of breast cancer cells through ROS-mediated mechanisms potentiates the lethality of paclitaxel by a novel diterpene, gelomulide K.,FREE RADICAL BIOLOGY AND MEDICINE,2011 Aug,51(3):641-657
SCI論文 李家琳(Chia-Lin Lee)、(Chi-Huan Huang)、(Hui-Chun Wang)、(Da-Wei Chuang)、(Ming-Jung Wu)、(Sheng-Yang Wang)、(Tsong-Long Hwang)、(Chin-Chung Wu)、(Yeh-Long Chen)、(Fang-Rong Chang)*、吳永昌*,First total synthesis of antrocamphin A and its analogs as anti-inflammatory and anti-platelet aggregation agents.,ORGANIC & BIOMOLECULAR CHEMISTRY,2011 Jan,9(1):70-73
SCI論文 (Yu-Ming Chung)、(Fang-Rong Chang)、(Tseng-Fu Tseng)、(Tsong-Long Hwang)、(Lei-Chin Chen)、(Shou-Fang Wu)、李家琳(Chia-Lin Lee)、(Zu-Yau Lin)、(Li-Yeh Chuang)、(Jinu-Huang Su)*、吳永昌*,A novel alkaloid, aristopyridinone A and anti-inflammatory phenanthrenes isolated from Aristolochia manshuriensis,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2011 ,21(6):1792-1794
SCI論文 (Shou-Fang Wu)、(Fang-Rong Chang)、(Sheng-Yang Wang)、(Tsong-Long Hwang)、李家琳(Chia-Lin Lee)、(Shu-Li Chen)、(Chin-Chung Wu)、吳永昌*,Anti-inflammatory and cytotoxic neoflavonoids and benzofurans from Pterocarpus santalinus,JOURNAL OF NATURAL PRODUCTS,2011 ,74(0):989-996
SCI論文 (Attila Hunyadi)、(Da-Wei Chuang)、(Balazs Danko)、(Michael Y. Chiang)、李家琳(Chia-Lin Lee)、(Hui-Chun Wang)、(Chin-Chung Wu)、(Fang-Rong Chang)*、吳永昌(Yang-Chang Wu)*,Direct Semi-Synthesis of the Anticancer Lead-Drug Protoapigenone from Apigenin, and Synthesis of Further New Cytotoxic Protoflavone Derivatives,PLoS One,2011 ,6(8):e23922
SCI論文 李家琳(Chia-Lin Lee)、(Yung-Chih Lia)、(Tsong-Long Hwang)、(Chin-Chung Wu)、(Fang-Rong Chang)*、吳永昌*,Ixorapeptide I and ixorapeptide II, bioactive peptides isolated from Ixora coccinea,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2010 Nov,20(*):7354-7357
SCI論文 李家琳(Chia-Lin Lee)、(Fang-Rong Chang)、(Ming-Hon Yen)、(Donglei Yu)、(Yi-Nan Liu)、(Kenneth F. Bastow)、(Susan L. Morris-Natschke)、吳永昌*、(Kuo-Hsiung Lee)*,Cytotoxic phenanthrenequinones and 9,10-dihydrophenanthrenes from Calanthe arisanensis,JOURNAL OF NATURAL PRODUCTS,2009 ,72(*):210-213
SCI論文 李家琳(Chia-Lin Lee)、(Lien-Chai Chiang)、(Li-Hung Cheng)、(Chih-Chuang Liaw)、(Mohamed H. Abd El-Razek)、(Fang-Rong Chang)*、吳永昌*,Anti-influenza A Viral (H1N1) and Cytotoxic Agents from Ferula assafoetida,JOURNAL OF NATURAL PRODUCTS,2009 ,72(*):1568-1572
SCI論文 李家琳(Chia-Lin Lee)、(Po-Ching Huang)、(Pei-Wen Hsieh)、(Tsong-Long Hwang)、(Chih-Chuang Liaw)、(Fang-Rong Chang)、吳永昌*,Chemical Constituents from Xanthium strumarium and (8S)-(-)-Xanthienopyran, a New Inhibitor of fMLP/CB induced Superoxide Anion Generation by Neutrophils,PLANTA MEDICA,2008 ,74(*):1276-1279
SCI論文 李家琳(Chia-Lin Lee)、(Kyoko Nakagawa-Goto)、(Donglei Yu)、(Yi-Nan Liu)、(Kenneth F. Bastow)、(Susan L. Morris-Natschke)、(Fang-Rong Chang)、吳永昌*、(Kuo-Hsiung Lee)*,Cytotoxic calanquinone A from Calanthe arisanensis and its first total synthesis,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2008 ,18(*):4275-4277
SCI論文 (Shou-Fang Wu)、(Pei-Wen Hsieh)、(Chin-Chung Wu)、李家琳(Chia-Lin Lee)、(Shu-Li Chen)、(Chi-Yu Lu)、(Tian-Shung Wu)、(Fang-Rong Chang)*、吳永昌*,Camptothecinoids from the seeds of Taiwanese Nothapodytes foetida,MOLECULES,2008 ,13(*):1361-1371
SCI論文 李家琳(Chia-Lin Lee)、(Fang-Rong Chang)、(Pei-Wen Hsieh)、(Michael-Y Chiang)、(Chin-Chung Wu)、(Zih-You Huang)、藍于琁(Lan Yu Hsuan)、(Mei Chen)、(Kuo-Hsiung Lee)、(Hsin-Fu Yen)、(Wen-Chun Hung)、吳永昌*,Cytotoxic ent-abietane diterpenes from Gelonium aequoreum,PHYTOCHEMISTRY,2008 ,69(*):276-287
 
研討會論文/Conference Papers
(發表主題或論文名稱,研討會名稱,演講地點,研討會期間,受邀演講題目)
1﹒ Developing Anti-melanogenesis Agents from a Traditional Chinese Medicine, Leonurus japonicus,第31屆天然藥物研討會藥學暨中醫藥學門成果發表會,高雄,2016.10.14 ~ 2016.10.15,
2﹒ Anti-Glucose Uptake Secondary Metabolites from Purple Ipomoea batatas Leaves,第31屆天然藥物研討會藥學暨中醫藥學門成果發表會,高雄,2016.10.14 ~ 2016.10.15,
3﹒ Anti-melanogenesis components from traditional Chinese medicine, Pharbitidis semen,第九屆 中國醫藥大學暨亞洲大學 生物科技研討會,台灣 台中,2016.3.14 ~ 2016.3.14,
4﹒ 中藥白及之抑制黑色素活性成分研究,2016兩岸中草藥產業交流研討會,台灣屏東,2016.3.18 ~ 2016.3.18,
5﹒ Antineutrophilic inflammatory secondary metabolites from Solanum macaonense,2015 63rd GA,布達佩斯,2015.8.23 ~ 2015.8.27,
6﹒ Anti-inflammatory and cytotoxic components from Dichrocephala integrifolia,第二十九屆天然藥物研討會,台灣 高雄,2014.9.27 ~ 2014.9.28,
7﹒ Anti-neutrophilic Inflammatory Secondary Metabolites from Traditional Chinese Medicine, Tiankuizi,第27屆 天然藥物研討會,臺灣/高雄,2012.10.6 ~ 2012.10.7,
8﹒ BIOACTIVE STEROIDAL GLYCOSIDES FROM SOLANUM TORVUM,2012 International Congress on Natural Products Research,美國/紐約州/紐約,2012.7.28 ~ 2012.8.1,
9﹒ CYTOTOXIC AND ANTIPLATELET AGGREGATION METABOLITES FROM CALANTHE ARISANENSIS,52ND ANNUAL MEETING OF THE AMERICAN SOCIETY OF PHARMACOGNOSY,美國/加州/聖地牙哥,2011.7.30 ~ 2011.8.3,
 
研究計畫/Research Grant
(研究類型,研究計畫代號,主持人,補助或委託單位名稱,計畫名稱,研究經費,計畫期間)
1﹒ 個別型,MOST 105-2320-B-039-047-MY3,李家琳(Chia-Lin Lee),江秀梅(Hsiu-Mei Chiang),科技部,中藥白蘞之抑制黑色素活性成分研究與開發,$1650000,2018.8.1 ~ 2019.7.31
2﹒ 個別型,MOST 105-2320-B-039-047-MY3,李家琳(Chia-Lin Lee),江秀梅(Hsiu-Mei Chiang),科技部,中藥白蘞之抑制黑色素活性成分研究與開發,$1600000,2017.8.1 ~ 2018.7.31
3﹒ 個別型,CMU105-S-27,李家琳(Chia-Lin Lee),本校(含附醫),中藥天花粉之美白活性成分分析,$230000,2016.9.7 ~ 2017.7.31
4﹒ 個別型,MOST 105-2320-B-039-047-MY3,李家琳(Chia-Lin Lee),江秀梅(Hsiu-Mei Chiang),科技部,中藥白蘞之抑制黑色素活性成分研究與開發,$1550000,2016.8.1 ~ 2017.7.31
5﹒ 個別型,MOST 103-2320-B-039-006-MY3,林應如(Ying-Ju Lin),蘇士哲、賴建成、陳錦華、李家琳(Chia-Lin Lee)、吳永昌(Yang-Chang Wu)、林振文(Lin Cheng Wen)、何宗融(Tsung-Jung Ho)、蔡輔仁(Fuu-Jen Tsai)、王任賢(Jen-Hsien Wang)、梁文敏(Wen-Miin Liang)、洪千惠,科技部,第一型愛滋病毒潛伏細胞活化之中藥活性分析與機轉探討,$1500000,2016.8.1 ~ 2017.7.31
6﹒ 學生參與計畫,105-2815-C-039-069-B,李家琳(Chia-Lin Lee),科技部,低溫萃竹笙調控黑色素生成能力之探討,$48000,2016.7.1 ~ 2017.2.28
7﹒ 個別型,MOST 103-2320-B-039-003-MY2,李家琳(Chia-Lin Lee),彭婕妤(Chieh-Yu Peng)、黃聰龍,科技部,毛柱萬桃花之抗發炎與抗癌活性成分探討,$1300000,2015.8.1 ~ 2016.7.31
8﹒ 個別型,MOST 103-2320-B-039-006-MY3,林應如(Ying-Ju Lin),蘇士哲、賴建成、陳錦華、李家琳(Chia-Lin Lee)、吳永昌(Yang-Chang Wu)、林振文(Lin Cheng Wen)、何宗融(Tsung-Jung Ho)、蔡輔仁(Fuu-Jen Tsai)、王任賢(Jen-Hsien Wang)、梁文敏(Wen-Miin Liang)、洪千惠,科技部,第一型愛滋病毒潛伏細胞活化之中藥活性分析與機轉探討,$1350000,2015.8.1 ~ 2016.7.31
9﹒ 學生參與計畫,104-2815-C-039-021-B,李家琳(Chia-Lin Lee),科技部,葛根抑制光老化活性及細胞訊息傳遞,$48000,2015.7.1 ~ 2016.2.28
10﹒ 個別型,MOST 103-2320-B-039-003-MY2,李家琳(Chia-Lin Lee),彭婕妤(Chieh-Yu Peng)、黃聰龍,科技部,毛柱萬桃花之抗發炎與抗癌活性成分探討,$1500000,2014.8.1 ~ 2015.7.31
11﹒ 個別型,MOST 103-2320-B-039-006-MY3,林應如(Ying-Ju Lin),蘇士哲、賴建成、陳錦華、李家琳(Chia-Lin Lee)、吳永昌(Yang-Chang Wu)、林振文(Lin Cheng Wen)、何宗融(Tsung-Jung Ho)、蔡輔仁(Fuu-Jen Tsai)、王任賢(Jen-Hsien Wang)、梁文敏(Wen-Miin Liang)、洪千惠,科技部,第一型愛滋病毒潛伏細胞活化之中藥活性分析與機轉探討,$1500000,2014.8.1 ~ 2015.7.31
12﹒ 個別型,CCMP102-RD-116,吳永昌(Yang-Chang Wu),李鳳琴(Hong-Zin Lee)、汪貴珍(Guei-Jane Wang)、彭文煌(Wen-Huang Peng)、曾彥學、黃琮竣(Tsurng-Juhn Huang)、周聖杰(Shen-Chieh Chou)、李家琳(Chia-Lin Lee),衛福部,臺灣本土藥用植物闊葉麥門冬與臺灣油點草之研究與開發(2-2),$1500000,2013.1.24 ~ 2013.12.15
13﹒ 個別型,CMU101-N1-09,李家琳(Chia-Lin Lee),吳永昌(Yang-Chang Wu),本校(含附醫),茄屬植物spirostanol saponin類化合物之抗發炎活性探討,$400000,2012.9.20 ~ 2013.7.31
14﹒ 個別型,CCMP101-RD-015,吳永昌(Yang-Chang Wu),李鳳琴(Hong-Zin Lee)、汪貴珍(Guei-Jane Wang)、彭文煌(Wen-Huang Peng)、曾彥學、黃琮竣(Tsurng-Juhn Huang)、周聖杰(Shen-Chieh Chou)、李家琳(Chia-Lin Lee),衛福部,臺灣本土藥用植物闊葉麥門冬與臺灣油點草之研究與開發(2-1),$1500000,2012.3.8 ~ 2012.12.15
15﹒ 個別型,NSC 100-2113-M-039-003,李家琳(Chia-Lin Lee),科技部,臺灣民間草藥-茯苓菜天然物成份之分離、結構優化之衍生物製備與其相關生物活性探討,$422000,2011.12.1 ~ 2012.7.31
16﹒ 個別型,DMR-100-174,李家琳(Chia-Lin Lee),吳永昌,附醫院內計畫,中藥天葵子之活性成分研究,$250000,2011.2.1 ~ 2011.12.31