姓名/Name: 林雲蓮 性別/Gender:
English Name:
1.中醫學院中國藥學暨中藥資源學系(教授) / Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources (Professor)
Email: yllin@mail.cmu.edu.tw
研究專長/Fields of Specialty
1﹒ 天然物化學(Natural Product Chemistry)
2﹒ 代謝體學 (Metabolomics)
3﹒ 中藥品質管制(Chemical Quality Control of Chinese Herbs
4﹒ 藥物開發(Drug Development)
5﹒ 生藥學 (Pharmacognosy)
6﹒ 有機光譜學(Organic Spectroscopy)
期刊論文/Journal Paper
SCI論文 許偉祥、(Yuh-Chiang Shen)、(Young-Ji Shiao)、(Ching-Hua Kuo)、(Chung-Kuang Lu)、(Tai-Yuan Lin)、(Wei-Chi Ku)、林雲蓮(LIN, YUN-LIAN)*,Combined proteomic and metabolomic analyses of cerebrospinal fluid from mice with ischemic stroke reveals the effects of a Buyang Huanwu decoction in neurodegenerative disease,PLoS One,2019 Jan,14(1):
SCI論文 江以文(Jiang Yi-Wen)、陳心于、郭昭麟(Kuo, Chao-Lin)、魏宗德(Tzong-Der Way)、連金城(Jin-Cherng Lien)、闕甫伈(Fu-Shin Chueh)、林雲蓮(LIN, YUN-LIAN)*、鍾景光(Jing-Gung Chung)*,Tetrandrine inhibits human brain glioblastoma multiforme GBM 8401 cancer cell migration and invasion in vitro,ENVIRONMENTAL TOXICOLOGY,2018 Dec,():
SCI論文 李蕙君(Hui-Chun Lee)*、林雲蓮(Lin, Yun-Lian)、黃彥鈞(Yen-Chun Huang)、蔡佳芬(Chia-Fen Tsai)、王德原(Der-Yuan Wang),Identification of a new tadalafil analogue, N-3-hydroxypropylnortadalafil, in a supplement product,JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2018 Jun,158():257-261
SCI論文 (Chen-Yuan Chiu)、(Wei-Hsiang Hsu)、(Hui-Kang Liu)、(Shing-Hwa Liu)、林雲蓮(Lin, Yun-Lian)*,Prepared Rehmanniae Radix Oligosaccharide Regulates Postprandial and Diabetic Blood Glucose in Mice,Journal of Functional Foods,2018 Feb,41():210-215
SCI論文 (Chuen-Lin Huang)、(Kaw-Chen Wang)、(Ying-Chen Yang)、(Chun-Tang Chiou)、(Chia-Hui Tan)、林雲蓮(Lin, Yun-Lian)、(Nai-Kuei Huang)*,Gastrodia elata alleviates mutant huntingtin aggregation through mitochondrial function and biogenesis mediation,PHYTOMEDICINE,2018 Jan,39(1):79-84
SCI論文 (I-Jung Lee)、(Cheng-Pei Chung)、張淑貞(Shu-Jen Chang)、林雲蓮(Yun-Lian Lin)*,Morphological and chemical analyses of Eriocauli Flos sold in Taiwan markets,JOURNAL OF FOOD AND DRUG ANALYSIS,2017 Oct,25(04):939-945
SCI論文 (Yen-Chun Huang)、(Lee, Hui-Chun)*、林雲蓮(Yun-Lian Lin)、(Ya-Tze Lin)、(Tsai, Chia-Fen)、(Cheng, Hwei-Fang),Identification of a new sildenafil analogue adulterant, desethylcarbodenafil, in a herbal supplement,Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure& Risk Assessment,2016 Dec,33(11):1637-1642
EI論文 (Lin, Ya-Tze)、(Huang, Yen-Chun)、(Lee, Hui-Chun)*、(Liao, Chen-Hsiang)、林雲蓮(Yun-Lian Lin)、(Tsai, Chia-Fen)、(Hwei-Fang Cheng),Isolation and identification of a novel sildenafil analogue adulterant in herbal products,Food Additives and Contaminants - Part A Chemistry,2016 Dec,():
SCI論文 (Yuh-Ching Twu)、(Tzong-Shyuan Lee)、林雲蓮(Yun-Lian Lin)、(Shih-Ming Hsu)、(Yuan-Hsi Wang)、(Chia-Yu Liao)、(Chung-Kwe Wang)、(Yu-Chih Liang)、(Yi-Jen Liao)*,Niemann-Pick Type C2 Protein Mediates Hepatic Stellate Cells Activation by Regulating Free Cholesterol Accumulation,INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2016 Jul,17(7):1122-1133
SCI論文 (Hui-Chun Lee)*、林雲蓮(Yun-Lian Lin),Identification of a new tadalafil analogue, dipropylaminopretadalafil, in a dietarysupplement.,Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure & Risk Assessment,2016 Jun,33(6):953-958
SCI論文 (Hong-Jhang Chen)、(Yii-Jeng Lin)、(Pei-Chen Wu)、(Wei-Hsiang Hsu)、(Wan-Chung Hu)、(Fang-Pey Chen)、林雲蓮(Yun-Lian Lin)*,Study on Yang-Xu Using Body Constitution Questionnaire and Blood Variables in Healthy Volunteers,Evidence-based Complementary and Alternative Medicine,2016 ,2016(2016):
SCI論文 (Ching-Fen Wu)、(Chunlan Hong)、(Sabine M. Klauck)、林雲蓮(Yun-Lian Lin)、(Thomas Efferth)*,Molecular mechanisms of rosmarinic acid from Salvia miltiorrhiza in acute lymphoblastic leukemia cells.,JOURNAL OF ETHNOPHARMACOLOGY,2015 Dec,176():55-68
SCI論文 (An-Hsun Chou)、(Ying-Ling Chen)、(Ching-Chi Chiu)、(Shin-Je Yuan)、(Yi-Hsin Weng)、(Tu-Hsueh Yeh)、林雲蓮(Yun-Lian Lin)、(Jim-Min Fang)、(Hung-Li Wang)*,T1-11 and JMF 1907 ameliorate polyglutamine-expanded ataxin-3-induced neurodegeneration transcriptional dysregulation and ataxic symptom in the SCA3 transgenic mouse.,NEUROPHARMACOLOGY,2015 Dec,99():308-317
SCI論文 (Hong-Jhang Chen)、(Yuh-Chiang Shen)、(Young-Ji Shiao)、(Kuo-Tong Liou)、(Wei-Hsiang Hsu)、(Pei-Hsuan Hsieh)、(Chi-Ying Lee)、Yet-Ran Chen*、林雲蓮(Yun-Lian Lin)*,Multiplex Brain Proteomic Analysis Revealed the Molecular Therapeutic Effects of Buyang Huanwu Decoction on Cerebral Ischemic Stroke Mice.,PLoS One,2015 Oct,10(10):
SCI論文 (Yuh-Chiang Shen)、(Chung-Kuang Lu)、(Kuo-Tong Liou)、(Yu-Chang Hou)、林雲蓮(Yun-Lian Lin)*、(Yea-Hwey Wang)、(Hsing-Jen Sun)、(Ko-Hsun Liao)、(Hsei-Wei Wang),Common and unique mechanisms of Chinese herbal remedies on ischemic stroke mice revealed by transcriptome analyses,JOURNAL OF ETHNOPHARMACOLOGY,2015 Jul,173():370-382
SCI論文 (Jyun-Siang Fan)、(I-Jung Lee)、林雲蓮(Yun-Lian Lin)*,Flavone glycosides from commercial available Lophatheri Herba and their quantitative determination.,JOURNAL OF FOOD AND DRUG ANALYSIS,2015 May,3(4):821-827
SCI論文 林雲蓮(Yun-Lian Lin)、(Huey-Jen Tsay)、(Tzu-Hsuan Lai)、(Tsai-Teng Tzeng)、(Young-Ji Shiao)*,Lithospermic acid attenuates 1-methyl-4-phenylpyridine-induced neurotoxicity by blocking neuronal apoptotic and neuro-inflammatory pathways.,JOURNAL OF BIOMEDICAL SCIENCE,2015 Mar,22(1):37-49
SCI論文 (Yu-Ju Liu)、(Tz-Chuen Ju)、(Hui-Mei Chen)、(Yu-Sung Jang)、(Li-Ming Lee)、(Hsing-Lin Lai)、(Hua-Chia Ta)、(Jim-Min Fang)、林雲蓮(Yun-Lian Lin)*、(Pang-Hsien Tu),Activation of AMP- activated protein kinase a1 mediates mislocalization of TDP-43 in amyotrophic lateral sclerosis.,HUMAN MOLECULAR GENETICS,2015 Feb,24(3):787-801
SCI論文 林雲蓮(Yun-Lian Lin)*,New Polyprenylated phloroglucinols from Hypericum sampsonii.,MOLECULES,2014 Nov,19(12):19836-19844
SCI論文 林雲蓮(Yun-Lian Lin)*,Glycyrrhetinic acid suppressed NF-κB activation in TNF-α-induced hepatocytes.,JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2014 Jan,62(3):618-625
研討會論文/Conference Papers
1﹒ Saccharides Related-profiling of Rehmanniae Radix during Processing,17th MEETING OF THE CONSORTIUM FOR GLOBALIZATION OF CHINESE MEDICINE (CGCM 2018),Borneo Convention Centre, Kuching Sarawak, Malaysia(馬來西亞),2018.8.8 ~ 2018.8.10,Saccharides Related-profiling of Rehmanniae Radix during Processing
2﹒ Urine Metabolomics Profile in Patients with Reversible Cerebral Vasoconstriction Syndrome,Metabolomics 2018,Seattle, Washington,2018.6.24 ~ 2018.6.28,
3﹒ Oligosaccharides from Prepared Rehmanniae Radix Regulates Postprandial and Diabetic Blood Glucose in Mice,生物醫學國際研討會暨第15屆前瞻生物醫學科學新知研討會,中國醫藥大學,2018.6.29 ~ 2018.6.30,
4﹒ Characterization of Saccharide Profile of Rehmanniae Radix during Processing,第十屆全球傳統醫學大學聯盟論壇 亞太整合醫學研討會,中國醫藥大學,2018.5.25 ~ 2018.5.26,
5﹒ Cerebrospinal fluid metabolomic characteristics of Buyang Huanwu Decoction in cerebral ischemic stroke mice,第1屆臺灣藥學聯合學術研討會,成功大學,2018.1.13 ~ 2018.1.14,
6﹒ Eriocauli Flos Sold in Taiwan Herbal Markets by Morphological and Chemical Analyses,The 32th International Symposium on Natural Products,中國醫藥大學,2017.10.13 ~ 2017.10.14,
7﹒ To Access Yin-Xu Using Body Constitution Questionnaire and Blood Variables in Male Healthy Volunteers,THE 16th MEETING OF CONSORTIUM FOR GLOBALIZATION OF CHINESE MEDICINE 2017,中國廣州,2017.8.18 ~ 2017.8.21,
8﹒ Eriocauli Flos Sold in Taiwan Herbal Markets by Morphological and Chemical Analyses,THE 16th MEETING OF CONSORTIUM FOR GLOBALIZATION OF CHINESE MEDICINE 2017,中國廣州,2017.8.18 ~ 2017.8.21,
9﹒ Metabolomics Characteristics of Buyang Huanwu Decoction in Cerebral Ischemic Stroke Mice,METABOLOMICS 2017,澳洲布里斯本,2017.6.26 ~ 2017.6.29,
10﹒ Anti-diabetic Activity of Prepared Rehmanniae Radix Oligosaccharide,第31屆天然藥物研討會藥學暨中醫藥學門成果發表會,國立中山大學海洋科學院,2016.10.14 ~ 2016.10.15,
11﹒ Survey of Commercially Available Eriocauli Flos in Taiwan Area,第31屆天然藥物研討會藥學暨中醫藥學門成果發表會,國立中山大學海洋科學院,2016.10.14 ~ 2016.10.15,
12﹒ Protein Candidates for the Neuroprotective Effect of Buyang Huanwu Decoction in Cerebral Ischemic Stroke Mice,第15屆中藥全球化聯盟會議,Academia Sinica, Taipei,2016.8.22 ~ 2016.8.26,
13﹒ Neuroprotective Effect of Buyang Huanwu Decoction in Cerebral Ischemic Stroke Mice.,International Sympossium of Biomedical Sciences.,台中中國醫藥大學,2016.7.1 ~ 2016.7.2,
14﹒ Characteristics of Yang-Xu Based on Body Constitution Questionnaire and Blood Clinical Variables in Healthy Volunteers,第18屆國際東洋醫學研討會 18th International Congress of Oriental Medicine,日本沖繩,2016.4.15 ~ 2016.4.17,
研究計畫/Research Grant
1﹒ 個別型,MOST 107-2320-B-039-001,林雲蓮(Lin, Yun-Lian),科技部,從代謝體及蛋白體研究探討腎陽虛與腎陰虛及補腎方右歸丸和七味都氣丸之療效-- 從動物實驗到臨床研究(2/3),$1500000,2018.8.1 ~ 2019.7.31
2﹒ 個別型,MOST 106-2320-B-039-053-,林雲蓮(Lin, Yun-Lian),高尚德(Kao, Shung-Te)、林麗娟(Lin, Li-Jen),科技部,從代謝體及蛋白體研究探討腎陽虛與腎陰虛及補腎方右歸丸和七味都氣丸之療效-- 從動物實驗到臨床研究(1/3),$1700000,2017.8.1 ~ 2018.7.31
3﹒ 整合型項下子計畫(主持人),MOST 106-2321-B-001-044,陳志成,韓德生、黃聖言、吳昭正、林建和、林雲蓮(Yun-Lian Lin),科技部,以纖維肌痛症與神經根病變為例探討痠與痛的生物指標(1/4),$2070000,2017.1.1 ~ 2017.12.31
4﹒ 個別型,106農科-16.1.2-桃-Y2,林雲蓮(Lin, Yun-Lian),農委會,106年度天麻抗老化機能性產品產業價值鏈之優化整合與加值推動-天麻萃取物緩解老化動物模型之驗證,$1058000,2017.1.1 ~ 2017.12.31
5﹒ 整合型項下子計畫(主持人),105農科-16.1.3-桃-Y2,林雲蓮(Yun-Lian Lin),,105年度「機能性產品產業價值鏈之優化整合與加值推動」之石斛護眼產品產業價值鏈之優化整合與加值推動,$841000,2016.2.1 ~ 2016.12.31
6﹒ 整合型項下子計畫(主持人),105農科-16.1.2-桃-Y2,林雲蓮(Yun-Lian Lin),,105年度「機能性產品產業價值鏈之優化整合與加值推動」之天麻抗老化機能性產品產業價值鏈之優化整合與加值推動,$1122000,2016.2.1 ~ 2016.12.31
7﹒ 個別型,MOST 103-2320-B-039 -055 -MY3,林雲蓮(Yun-Lian Lin),,中藥複方的療效評估--從代謝體研究探討補陽還五湯及血府逐瘀湯對缺血型中風小鼠的療效,$2348706,2015.8.1 ~ 2017.7.31
8﹒ 個別型,MOST 103-2320-B-039 -055 -MY3,林雲蓮(Yun-Lian Lin),科技部,中藥複方的療效評估--從代謝體研究探討補陽還五湯及血府逐瘀湯對缺血型中風小鼠的療效,$3750000,2014.8.1 ~ 2017.7.31
2﹒ 皮膚美白用化合物及皮膚用組成物,發明專利,台灣,I426926,2014.2.21 ~ 2033.1.10
3﹒ Dual-action compounds targeting adenosine receptors and transporters for prevention and treatment of neurodegenerative diseases,發明專利,台灣,I398255,2013.6.11 ~ 2030.11.11
4﹒ Method of Making and Using an Adenosine Analogue,發明專利,台灣,I372627,2012.3.6 ~ 2029.6.8
6﹒ Therapeutic Gastrodia Extracts,發明專利,台灣,I369213,2006.4.7 ~ 2026.4.6