學術研究成果/Publication
基本資料/Profiles
姓名/Name: 李建興 性別/Gender:
英文姓名/
English Name:
Chien-Hsing Lee 英文縮寫/
Abbreviation:
任職單位/
Affiliation:
1.中醫學院中醫學系學士班中醫外傷學科(教授) / School of Chinese Medicine- Surgical Trauma (Professor)
2.兒童醫院小兒外科(副院長) / Pediatric Surgery (Vice Superintendent)
Email: hsing27566@mail.cmu.edu.tw
研究專長/Fields of Specialty
1﹒ Nutrition,Arginine
2﹒ Immune
3﹒ Cancer
4﹒ Animal model
5﹒ Surgical Nutrition
6﹒ Pediatric Surgery and Neonatal Surgery
7﹒ Oncology
 
期刊論文/Journal Paper
(作者群,論文題目,期刊名稱,出版年月,卷號(期別):頁次起迄)
SCI論文 (Wen-Tzu Wu)、(Tai-Hao Hsu)、李建興(Chien-Hsing Lee)、(Hui-Chen Lof)*,Fruiting Bodies of Chinese Caterpillar Mushroom, Ophiocordyceps sinensis (Ascomycetes) Alleviate Diabetes-Associated Oxidative Stress,INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS,2020 May,22(1):15-29
SCI論文 (Hui-Chen Lo)、(Tai-Hao Hsu)、李建興(Chien-Hsing Lee)*,Extracellular Polysaccharopeptides from Fermented Turkey Tail Medicinal Mushroom, Trametes versicolor (Agaricomycetes), Mitigate Oxidative Stress, Hyperglycemia, and Hyperlipidemia in Rats with Type 2 Diabetes Mellitus,INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS,2020 May,22(5):417-429
SCI論文 (Yi-Hsien Hsieh)、(Ru-Jiang Syu)、(Chu-Che Lee)、(Shin-Huey Lin)、李建興(Chien-Hsing Lee)、(Chun-Wen Cheng)、(Jen-Pi Tsai)*,Arecoline induces epithelial mesenchymal transition in HK2 cells by upregulating the ERK-mediated signaling pathway,ENVIRONMENTAL TOXICOLOGY,2020 Apr,10(1002):22937
SCI論文 曾采藝(TSENG TSAIYI)、(Hui-Ling Chiou)、(Chiao ? Wen Lin)、(Yong-Syuan Chen)、(Li-Sung Hsu)、李建興(Chien-Hsing Lee)*、(Yi-Hsien Hsieh)*,Repression of metastasis-associated protein 2 for inhibiting metastasis of human oral cancer cells by promoting the p-cofilin-1/LC3-II expression,JOURNAL OF ORAL PATHOLOGY & MEDICINE,2019 Jul,():
SCI論文 (Chun-Shiang Lin)、(Chia-Liang Lin)、(Hui-Ling Chiou)、李建興(Chien-Hsing Lee)、(Chia-Hung Hung)、(Yi-Hsien Hsieh)*、(Shao-Hsuan Kao)*,β-Mangostin Suppresses Mobility and Invasiveness of Cervical Cancer Cells via Inhibiting JNK-Mediated AP-1/Snail/ Integrin Axis,CELLULAR PHYSIOLOGY AND BIOCHEMISTRY,2019 Jan,2019(52):1687-1702
SCI論文 (Ching-Yi Hung)、李建興(Chien-Hsing Lee)、(Hui-Ling Chiou)、(Chia-Liang Lin)、(Pei-Ni Chen)、(Ming-Te Lin)、(Yi-Hsien Hsieh)*、(Ming-Chih Chou)*,Praeruptorin-B Inhibits 12-O-Tetradecanoylphorbol-13-Acetate– Induced Cell Invasion by Targeting AKT/ NF-κB via Matrix Metalloproteinase-2/-9 Expression in Human Cervical Cancer Cells,CELLULAR PHYSIOLOGY AND BIOCHEMISTRY,2019 Jan,2019(52):77-88
SCI論文 (Ju-Fang Teng)、李建興(Chien-Hsing Lee)、(Tai-Hao Hsu)、(Hui-Chen Lo)*,Potential activities and mechanisms of extracellular polysaccharopeptides from fermented Trametes versicolor on regulating glucose homeostasis in insulin-resistant HepG2 cells,PLoS One,2018 Jul,13(7):1-18
SCI論文 (Chia-Liang Lin)、李建興(Lee, Chien-Hsing)、(Chien-Min Chen)、(Chun-Wen Cheng)、(Pei-Ni Chen)、(Tsung-Ho Ying)、(Yi-Hsien Hsieh)*,Protodioscin Induces Apoptosis Through ROS-Mediated Endoplasmic Reticulum Stress via the JNK/p38 Activation Pathways in Human Cervical Cancer Cells,CELLULAR PHYSIOLOGY AND BIOCHEMISTRY,2018 Mar,2018(46):322-334
SCI論文 (Chu-Liang Lin)、(Chien-Min Chen)、(Chia-Liang Lin)、(Chun-Wen Cheng)、李建興(Lee, Chien-Hsing)*、(Yi-Hsien Hsieh)*,Norcantharidin induces mitochondrial-dependent apoptosis through Mcl-1 inhibition in human prostate cancer cells,BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH,2017 Jul,1864(2017):1867-1876
SCI論文 李建興(Chien-Hsing Lee)、(Tsung-Ho Ying)、(Hui-Ling Chiou)、(Shu-Ching Hsieh)、(Shiua-Hua Wen)、鄒瑞煌(Ruey-Hwang Chou)*、(Yi-Hsien Hsieh)*,Alpha-mangostin induces apoptosis through activation of reactive oxygen species and ASK1/p38 signaling pathway in cervical cancer cells,Oncotarget,2017 May,2017():1-15
SCI論文 (Tung-Wei Hung)、(Jen-Pi Tsai)、(Shin-Huey Lin)、李建興(Chien-Hsing Lee)、(Yi-Hsien Hsieh)*、(Horng-Rong Chang)*,Pentraxin 3 Activates JNK Signaling and Regulates the Epithelial-To-Mesenchymal Transition in Renal Fibrosis,CELLULAR PHYSIOLOGY AND BIOCHEMISTRY,2016 Dec,2016(40):1029-1038
SCI論文 (Tsung-Ho Ying)、李建興(Chien-Hsing Lee)、(Hui-Ling Chiou)、(Shun-Fa Yang)、(Chu-Liang Lin)、(Chia-Hung Hung)、(Jen-Pi Tsai)、(Yi-Hsien Hsieh)*,Knockdown of Pentraxin 3 suppresses tumorigenicity and metastasis of human cervical cancer cells,Scientific Reports,2016 Jul,5(6):
SCI論文 (Hui-Chen Lo)、洪靜宜(Ching-Yi Hung)、黃富煥(Fu-Huan Huang)、(Tzu-Cheng Su)、李建興(Chien-Hsing Lee)*,The Nitric Oxide Synthase Inhibitor NG-Nitro-L-Arginine Methyl Ester Diminishes the Immunomodulatory Effects of Parental Arginine in Rats with Subacute Peritonitis,PLoS One,2016 Mar,10(1371):1-18
SCI論文 黃富煥(Fu-Huan Huang)、李建興(Chien-Hsing Lee)*、曾采藝(TSENG TSAIYI)、洪靜宜(Ching-Yi Hung),Another Type of Choledochal Cyst Beyond the Todani Classification,INTERNATIONAL SURGERY,2016 Feb,101(1-2):54-57
SCI論文 (Chun-Hong Lai)、李建興(Chien-Hsin Lee)、(Ching-Yi Hung)、(Hui-Chen Lo)*,Oral Citrulline Mitigates Inflammation and Jejunal Damage via the Inactivation of Neuronal Nitric Oxide Synthase and Nuclear Factor–κB in Intestinal Ischemia and Reperfusion,JOURNAL OF PARENTERAL AND ENTERAL NUTRITION,2016 Jan,XX(XX):1-14
SCI論文 (Hsieh YH)、(Hsieh SC)、李建興(Chien-Hsin Lee)、(Yang SF)、(Cheng CW)、(Tang MJ)、(Chia-Liang Lin)、(Lin CL)、鄒瑞煌(Ruey-Hwang Chou)*,Targeting EMP3 suppresses proliferation and invasion of hepatocellular carcinoma cells through inactivation of PI3K/Akt pathway,Oncotarget,2015 Oct,6(33):34859-34874
SCI論文 (Ya-Hui Chen)、李建興(Chien-Hsin Lee)、(Tai-Hao Hsu)、(Hui-Chen Lo)*,Submerged-Culture Mycelia and Broth of the Maitake Medicinal Mushroom Grifola frondosa (Higher Basidiomycetes) Alleviate Type 2 Diabetes-Induced Alterations in Immunocytic Function,INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS,2015 Aug,17(6):541-556
SCI論文 (Jen-Pi Tsai)、李建興(Chien-Hsin Lee)、(Tsung-Ho Ying)、(Chu-Liang Lin)、(Chia-Liang Lin)、(Jung-Tsung Hsueh)、(Yi-Hsien Hsieh)*,Licochalcone A induces autophagy through PI3K/Akt/mTOR inactivation and autophagy suppression enhances Licochalcone A-induced apoptosis of human cervical cancer cells,Oncotarget,2015 Jul,6(30):28851-28866
 
研討會論文/Conference Papers
(發表主題或論文名稱,研討會名稱,演講地點,研討會期間,受邀演講題目)
1﹒ Meconium peritonitis with jejunal atresia caused by duplication cyst torsion,臺灣小兒外科醫學會第六十五次學術演講會,中國醫藥大學安康教學大樓二樓K205講堂,2019.9.21 ~ 2019.9.21,
2﹒ ,臺灣小兒外科醫學會第六十五次學術演講會,中國醫藥大學安康教學大樓二樓K205講堂,2019.9.21 ~ 2019.9.21,
3﹒ Laparoscopic toal colectomy for adolescent boy with Crohn's disease: A case report,52nd Annual Meeting of the Pacific Association of Pediatric Surgeons,Town Hall, Christchurch,2019.3.10 ~ 2019.3.14,
4﹒ 早產兒氣腹症無腸胃道穿孔,台灣外科醫學會第78次學術演講會(108年度外科聯合學術演講會),國防醫學院,2019.3.16 ~ 2019.3.17,
5﹒ Rare Ureteropelvic Junction Obstruction:A Case Report and Literature Review,台灣小兒外科醫學會 中區學術討論會,童綜合醫院梧棲院區-國際醫療轉送樓1樓會議室,2018.6.2 ~ 2018.6.2,
6﹒ Duodenojejunal atresia with "apple-peel" appearance of small intestine and malrotation,The 51st Annual Meeting of the Pacific Association of Pediatric Surgeons,Sapporo, Japan,2018.5.14 ~ 2018.5.17,
7﹒ Duodenojejunal atresia with “apple-peel” appearance of small intestine and malrotation,107年度外科聯合學術演講會,台北國防醫學院,2018.3.17 ~ 2018.3.18,
8﹒ 兒童外科門診常見的問題及處理方針,基層常見兒童外科症狀研討會,中國醫藥大學附設醫院 癌症大樓1樓階梯會議室,2016.8.7 ~ 2016.8.7,兒童外科門診常見的問題及處理方針
9﹒ Synergistic effects of glutamine, citrulline, and antioxidant vitamin C and E on modulating splenocytic immune responses in rats with intestinal ischemia and reperfusion,Experimental Biology 2016 San Diego,San Diego,2016.4.2 ~ 2016.4.6,
10﹒ 探討精胺酸、麩醯胺酸或胺基酸混合液為復甦輸液時大白鼠因創傷出血性休克引起的發炎反應及器官損傷,105年度外科聯合學術演講會暨小兒外科醫學會第58次學術演講會,台大醫學院403講堂,2016.3.19 ~ 2016.3.19,
11﹒ ,全人的兒童血液腫瘤照護:早期發現到最先進治療,中國醫藥大學附設醫院癌症大樓一樓階梯會議室,2016.2.21 ~ 2016.2.21,常見兒童一般及惡性腫瘤的早期表現
12﹒ Precocious pseudopuberty due to functional ovarian cysts,104年小兒外科中區學術研討會,台中榮民總醫院,2015.12.5 ~ 2015.12.5,
 
研究計畫/Research Grant
(研究類型,研究計畫代號,主持人,補助或委託單位名稱,計畫名稱,研究經費,計畫期間)
1﹒ 個別型,M08A7428,林忠(Chieh-Chung Lin),李建興(Chien-Hsing Lee)、巫康熙(Kang-Hsi Wu)、王仲興(Chung-Hsing Wang)、徐宗正(Tsung-Cheng Shyu)、謝右文(Yow-Wen Hsieh)、楊榮林(Rong-Lin Yang)、陳信泰(CHEN HSIN-TAI)、許祜川(Hu-Chuan Hsu)、鄭啟在(Chi-Tsai Cheng)、廖俊明(Chun-Ming Liao)、莊慧專(Hui-Chuan Chuang)、陳曉樺(Xiao-Hua Chen)、徐宜蓁(HSU YI-CHEN),衛福部,108-109年度兒童困難取得之臨床必要藥品及醫材調度中心計畫,$5150000,2020.1.1 ~ 2020.12.31
2﹒ 個別型,DMR-109-046,李建興(Chien-Hsing Lee),謝逸憲,附醫院內計畫,研究趨化激素-17在腎臟纖維化之角色,$400000,2019.8.1 ~ 2020.7.31
3﹒ 個別型,MOST 105-2320-B-040 -002 -MY3,謝逸憲,李建興(Lee, Chien-Hsing),科技部,研究去甲斑蝥素誘導miR-320d/miR-410來調控粒線體凋亡途徑及作為前列腺癌輔助荷爾蒙療法及放射線療法之分子機制,$1400000,2018.8.1 ~ 2019.7.31
4﹒ 個別型,MOST 105-2320-B-030 -003 -MY3,羅慧珍,徐泰浩、李建興(Lee, Chien-Hsing),科技部,以營養製劑改變腸道環境及免疫力對短腸症候群臨床預後的影響:全靜脈營養大鼠臨床前試驗,$1289000,2018.8.1 ~ 2019.7.31
5﹒ 個別型,DMR-108-049,李建興(Chien-Hsing Lee),謝逸憲,附醫院內計畫,白花前胡素B抑制TPA誘導人類子宮頸癌細胞轉移作用,$300000,2018.8.1 ~ 2019.7.31
6﹒ 整合型(召集人、總主持人),DMR-107-046,李建興(Lee, Chien-Hsing),謝逸憲,附醫院內計畫,研究多型性神經膠母細胞瘤之生物標誌蛋白和其調控之分子機制,$300000,2017.8.1 ~ 2018.7.31
7﹒ 個別型,DMR-107-054,李建興(Lee, Chien-Hsing),謝逸憲,附醫院內計畫,研究miR-7在子宮頸癌細胞轉移之機制,$300000,2017.8.1 ~ 2018.7.31
8﹒ 個別型,MOST 105-2320-B-040 -002 -MY3,謝逸憲,李建興(Lee, Chien-Hsing),科技部,研究去甲斑蝥素誘導miR-320d/miR-410來調控粒線體凋亡途徑及作為前列腺癌輔助荷爾蒙療法及放射線療法之分子機制,$1200000,2017.8.1 ~ 2018.7.31
9﹒ 個別型,MOST 105-2320-B-030 -003 -MY3,羅慧珍,徐泰浩、李建興(Lee, Chien-Hsing),科技部,以營養製劑改變腸道環境及免疫力對短腸症候群臨床預後的影響:全靜脈營養大鼠臨床前試驗,$1289000,2017.8.1 ~ 2018.7.31
10﹒ 個別型,DMR-106-043,李建興(Chien-Hsing Lee),謝逸憲,附醫院內計畫,P2X7嘌呤受體在人類肝癌之角色,$300000,2016.8.1 ~ 2017.7.31
11﹒ 個別型,DMR-106-049,李建興(Chien-Hsing Lee),謝逸憲,附醫院內計畫,研究甘草查爾酮A抗人類惡性膠質瘤細胞轉移和誘導細胞自噬作用之機制,$300000,2016.8.1 ~ 2017.7.31
12﹒ 個別型,DMR-106-169,曾采藝(TSENG TSAIYI),李建興(Chien-Hsing Lee)、吳青峰(Ching-Feng Wu),附醫院內計畫,豬之原位性腸移植,$200000,2016.8.1 ~ 2017.6.30
13﹒ 個別型,MOST 105-2320-B-030-003-MY3,羅慧珍,徐泰浩、李建興(Chien-Hsing Lee),科技部,以營養製劑改變腸道環境及免疫力對短腸症候群臨床預後的影響:全靜脈營養大鼠臨床前試驗,$1289000,2016.8.1 ~ 2017.7.31
14﹒ 個別型,MOST 105-2320-B-040-002-MY3,謝逸憲,李建興(Chien-Hsing Lee),科技部,研究去甲斑螯素誘導miR-320d/miR-410來調控粒線體凋亡途徑及作為前列腺癌輔助賀爾蒙療法及放射線療法之分子機制,$1300000,2016.8.1 ~ 2017.7.31
15﹒ 個別型,B10506222-1/2,巫康熙(Kang-Hsi Wu),彭慶添(Ching-Tien Peng)、楊義明(教授)、李建興(Chien-Hsing Lee)、郭煌宗(Haung-Tsung Kuo)、陳潓誼(Hui-Yi Chen)、陳旆聿(Pei-Yu Chen)、楊世能(Shih-Neng Yang)、鄭宇凱(Yu-Kai Cheng)、張建國(Jan-Gowth Chang),衛福部,兒童癌症方案-兒癌團隊全人全程照護:最先進的治療,最人性的照護,$962500,2016.6.22 ~ 2016.12.31
16﹒ 個別型,B1041124-1,巫康熙(Kang-Hsi Wu),彭慶添(Ching-Tien Peng)、楊義明(教授)、李建興(Chien-Hsin Lee)、郭煌宗(Haung-Tsung Kuo)、陳潓誼(Hui-Yi Chen)、陳旆聿(Pei-Yu Chen)、楊世能(Shih-Neng Yang)、鄭宇凱(Yu-Kai Cheng)、張建國(Jan-Gowth Chang),衛福部,兒童癌症方案-兒癌團隊全人全程照護:最先進的治療,最人性的照護,$1600000,2015.11.24 ~ 2016.3.31
17﹒ 個別型,DMR-105-035,李建興(Chien-Hsin Lee),謝逸憲,附醫院內計畫,探討MTA2在人類口腔癌之生物功能,$300000,2015.8.1 ~ 2016.7.31
18﹒ 個別型,DMR-105-043,李建興(Chien-Hsin Lee),謝逸憲、鄒瑞煌,附醫院內計畫,探討 EZH2 於乳癌治療的應用潛力,$300000,2015.8.1 ~ 2016.7.31