學術研究成果/Publication
基本資料/Profiles
姓名/Name: 洪宏杰 性別/Gender:
英文姓名/
English Name:
英文縮寫/
Abbreviation:
Hong, HJ
任職單位/
Affiliation:
1.中醫學院中醫學系學士班中醫基礎學科(副教授) / School of Chinese Medicine- Basic Chinese Medicine (Associate Professor)
Email: hongjh@mail.cmu.edu.tw
研究專長/Fields of Specialty
1﹒ 生命科學
2﹒ 循環藥理學
3﹒ 中藥藥理學
 
期刊論文/Journal Paper
(作者群,論文題目,期刊名稱,出版年月,卷號(期別):頁次起迄)
SCI論文 (Chun-Chao Chen)、洪宏杰、(Wen-Rui Hao)、鄭志鴻(CHENG, TZU-HURNG)、(Ju-Chi Liu)、(Li-Chin Sung)*,Nicorandil prevents doxorubicin-induced human umbilical vein endothelial cell apoptosis,EUROPEAN JOURNAL OF PHARMACOLOGY,2019 Sep,859(2019):172542-1-172542-8
SCI論文 (Wen-Rui Hao)、(Li-Chin Sung)、(Chun-Chao Chen)、洪宏杰*、(Ju-Chi Liu)*、陳錦澤(Jin-Jer Chen),Cafestol Activates Nuclear Factor Erythroid-2 Related Factor 2 and Inhibits Urotensin II-Induced Cardiomyocyte Hypertrophy,AMERICAN JOURNAL OF CHINESE MEDICINE,2019 Apr,57():30-38
SCI論文 高尚德(Kao, Shung-Te)、郭悅雄(Kuo, Yueh-Hsiung)、王舜德(Wang, Shulhn-Der)、洪宏杰(Hong, Hong-Jye)、林麗娟(Lin, Li-Jen)*,Analogous corticosteroids, 9A and EK100, derived from solid-state-cultured mycelium of Antrodia camphorata inhibit proinflammatory cytokine expression in macrophages,CYTOKINE,2018 Aug,108():136-144
SCI論文 (Shaowei Zhuang)、鄭志鴻(CHENG, TZU-HURNG)、(Nang-Lang Shih)、(Ju-Chi Liu)、陳錦澤(Jin-Jer Chen)、洪宏杰(Hong, Hong-Jye)*、(Paul Chan),Tanshinone IIA induces heme oxygenase 1 expression and inhibits cyclic strain-induced interleukin 8 expression in vascular endothelial cells.,AMERICAN JOURNAL OF CHINESE MEDICINE,2016 Apr,44(2):377-388
SCI論文 (Hung-Hsing Chao)、洪宏杰(Hong, Hong-Jye)、鄭志鴻(CHENG, TZU-HURNG)、(Neng-Lang Shih)、(Shih-Hurng Loh)、(Ju-Chi Liu)、陳錦澤(Jin-Jer Chen)、(Li-Chin Sung)*,Nicorandil Inhibits Cyclic Strain-Induced Interleukin-8 Expression in Human Umbilical Vein Endothelial Cells,PHARMACOLOGY,2016 Apr,98():42-50
SCI論文 (Li-Chin Sung)、(Hung-Hsing Chao)、(Cheng-Hsien Chen)、(Jen-Chen Tsai)、(Ju-Chi Liu)、洪宏杰(Hong, Hong-Jye)*、鄭志鴻(CHENG, TZU-HURNG)*、陳錦澤(Jin-Jer Chen),Lycopene inhibits cyclic strain-induced endothelin-1 expression through the suppression of reactive oxygen species generation and induction of heme oxygenase-1 in heman umbilical vein endothelial cells,CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,2015 Jun,42():632-639
SCI論文 林志哲(Chih-Che Lin)、王舜德(Shulhn-Der Wang)、林麗娟(Li-Jen Lin)、洪宏杰(Hong, Hong-Jye)、吳晉任(Chin-Jen Wu)、姜中人(Chung-Jen Chiang)、趙雲鵬(Yun-Peng Chao)、高尚德(Shung-Te Kao)*,Reduction of airway hyperresponsiveness by KWLL in Dermatophagoides pteronyssinus challenged mice,Evidence-based Complementary and Alternative Medicine,2013 May,2013():
SCI論文 陳保羅(Paul Chan)、(Yen-Cheng Chen)、林麗娟(Li-Jen Lin)、鄭志鴻(CHENG, TZU-HURNG)、(Kazunori Anzai)、(Yin-Ha Chen)、(Zhong-Min Liu)、林昭庚(Jaung-Geng Lin)、洪宏杰(Hong, Hong-Jye)*,Tanshinone IIA Attenuates H(2)O(2) -Induced Injury in Human Umbilical Vein Endothelial Cells,AMERICAN JOURNAL OF CHINESE MEDICINE,2012 Oct,40(6):1307-1319
SCI論文 洪宏杰(Hong, Hong-Jye)、劉如濟、陳柏源(Po-Yuan Chen)、陳錦澤(Jin-Jer Chen)、(Paul Chan)、鄭志鴻(CHENG, TZU-HURNG)*,Tanshinone IIA prevents doxorubicin-induced cardiomyocyte apoptosis through Akt-dependent pathway,INTERNATIONAL JOURNAL OF CARDIOLOGY,2012 May,157(2012):174-179
SCI論文 洪宏杰(Hong, Hong-Jye)、陳柏源(Po-Yuan Chen)*、施子卿(TZU-CHING SHIH)、歐哲延(CHE-YEN OU)、周旻德(MIEN-DE JHUO)、黃彥宇(YEN-YU HUANG)、程家興(CHIA-HSING CHENG)、(YU-CHI WU2)、鍾景光(Jing-Gung Chung)*,Computational pharmaceutical analysis of anti-Alzheimer's Chinese medicine Coptidis Rhizoma alkaloids,Molecular Medicine Reports,2012 Jan,5(1):142-147
SCI論文 洪宏杰(Hong, Hong-Jye)、(Hsu FL)、蔡士彰(Shih-Chang Tsai)、(Lin CH)、劉如濟、陳錦澤(Jin-Jer Chen)、鄭志鴻(CHENG, TZU-HURNG)*、(Chan P)*,Tanshinone IIA attenuates cyclic strain-induced endothelin-1 expression in human umbilical vein endothelial cells.,CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,2012 Jan,39(1):63-68
SCI論文 趙洪興(Hung-Hsing Chao)、洪宏杰(Hong, Hong-Jye)、(Li-Chin Sung)、陳錦澤(Jin-Jer Chen)、鄭志鴻(CHENG, TZU-HURNG)*、劉如濟*,Nicorandil attenuates cyclic strain-induced endothelin-1 expression via the induction of activating transcription factor 3 in human umbilical vein endothelial cells,EUROPEAN JOURNAL OF PHARMACOLOGY,2011 Sep,667(1-3):292-297
SCI論文 (Jer-Young Liou)、洪宏杰(Hong, Hong-Jye)、(Li-Chin Sung)、(Hung-Hsing Chao)、(Pao-Yun Chen)、鄭志鴻(CHENG, TZU-HURNG)、(Paul Chan)*、(Ju-Chi Liu),Nicorandil Inhibits Angiotensin-II-Induced Proliferation of Cultured Rat Cardiac Fibroblasts,PHARMACOLOGY,2011 Mar,87(3-4):144-151
SCI論文 (Chao, Hung-Hsin)、(Liu, Ji-Chi)、洪宏杰(Hong, Hong-Jye)、(Lin, Jia-Wei)、(Chen, Cheng-Hsien)、鄭志鴻(CHENG, TZU-HURNG)*,L-carnitine reduces doxorubicin-induced apoptosis through a prostacyclin-mediated pathway in neonatal rat cardiomyocytes,INTERNATIONAL JOURNAL OF CARDIOLOGY,2011 Feb,146(2011):145-152
SCI論文 (Paul Chan)、(Ju-Chi Liu)、林麗娟(Li-Jen Lin)、陳柏源(Po-Yuan Chen)、(Tzu-Hurng Cheng)、林昭庚(Jaung-Geng Lin)、洪宏杰(Hong, Hong-Jye)*,Tanshinone IIA Inhibits Angiotensin II-induced Cell Proliferation in Rat Cardiac Fibroblasts,AMERICAN JOURNAL OF CHINESE MEDICINE,2011 Feb,39(2):1-14
SCI論文 洪宏杰(Hong, Hong-Jye)、劉如濟、鄭志鴻(CHENG, TZU-HURNG)*、(Paul CHAN),Tanshinone IIA attenuates angiotensin II-induced apoptosis via Akt pathway in neonatal rat cardiomyocytes,ACTA PHARMACOLOGICA SINICA,2010 Dec,31(12):1569-1575
SCI論文 趙洪興(Chao HH)、洪宏杰、劉如濟(Liu JC)、林家瑋(Lin JW)、陳燕玲(Chen YL)、邱文達(Chiu WT)、吳介信(Chieh-Hsi Wu)、徐國基(Shyu KG)、鄭志鴻(CHENG, TZU-HURNG)*,Leptin stimulates endothelin-1 expression via extracellular signal-regulated kinase by epidermal growth factor receptor transactivation in rat aortic smooth muscle cells.,EUROPEAN JOURNAL OF PHARMACOLOGY,2007 Nov,573(1-3):49-54
SCI論文 黃家樂(Kar-Lok Wong)、吳憬全(Ching-Chuan Wu)、吳世銓(Rick Sai-Chuen Wu)、(Yu-Hsiang Chou)、鄭志鴻(CHENG, TZU-HURNG)、洪宏杰*,Tetramethylpyrazine Inhibits Angiotensin II-Increased NAD(P)H Oxidase Activity and Subsequent Proliferation in Rat Aortic Smooth Muscle Cells,AMERICAN JOURNAL OF CHINESE MEDICINE,2007 ,35(6):1021-1035
Other論文 洪宏杰(Hong,Hong-Jye)、張永賢(Chang,Yung-Hsien)、關超然(Chiu-Yin Kwan),血管緊張素II在血管中經由氧化張力引起的信號傳遞,華夏醫藥,2006 Nov,6(1):413-414
SCI論文 (Chen HH)、洪宏杰、(Chou YH)、鄭志鴻(CHENG, TZU-HURNG)、(Chen JJ)、(Lin H),Inhibition of Cyclic Strain-induced Endothelin-1 Secretion by Baicalein in Human Umbilical Vein Endothelial Cells.,PLANTA MEDICA,2006 Nov,14(72):1318-1321
SCI論文 黃家樂(WONG KAR-LOK)、(Lin JW)、(Liu JC)、(Yang HY)、(Kao PF)、陳強琛(Chen Chan-Cheng)、(Loh SH)、(Chiu WT)、鄭志鴻(CHENG, TZU-HURNG)、林昭庚(Lin JG)、洪宏杰*,Antiproliferative Effect of Isosteviol on Angiotensin-II-Treated Rat Aortic Smooth Muscle Cells.,PHARMACOLOGY,2006 Mar,76(4):163-169
SCI論文 (Liu JC)、(Chan P)、(Chen JJ)、(Lee HM)、(Lee WS)、(Shih NL)、(Chen YL)、洪宏杰、(Cheng TH),The inhibitory effect of trilinolein on norepinephrine-induced beta-myosin heavy chain promoter activity, reactive oxygen species generation, and extracellular signal-regulated kinase phosphorylation in neonatal rat cardiomyocytes.,JOURNAL OF BIOMEDICAL SCIENCE,2004 Jan,11(1):11-18
SCI論文 洪宏杰、(Liu JC)、(Chan P)、(Juan SH)、(Loh SH)、林昭庚(Jaung-Geng Lin)、鄭志鴻(CHENG, TZU-HURNG)*,17beta-estradiol downregulates angiotensin-II-induced endothelin-1 gene expression in rat aortic smooth muscle cells,JOURNAL OF BIOMEDICAL SCIENCE,2004 ,11(1):27-36
SCI論文 (Cheng CM)、洪宏杰、(Liu JC)、(Shih NL)、(Juan SH)、(Loh SH)、(Chan P)、(Chen JJ)、鄭志鴻(CHENG, TZU-HURNG)*,Crucial role of extracellular signal-regulated kinase pathway in reactive oxygen species-mediated endothelin-1 gene expression induced by endothelin-1 in rat cardiac fibroblasts.,MOLECULAR PHARMACOLOGY,2003 May,63(5):1002-1011
SCI論文 洪宏杰、(Hsiao G)、(Cheng TH)、(Yen MH)*,Supplemention with tetrahydrobiopterin suppresses the development of hypertension in spontaneously hypertensive rats.,HYPERTENSION,2001 Nov,38(5):1044-1048
SCI論文 (Tsai CS)、(Cheng TH)、(Lin CI)、(Chen JJ)、(Lee FY)、(Li CY)、洪宏杰、(Loh SH*)*,Inhibitory effect of endothelin-1 on the isoproterenol-induced chloride current in human cardiac myocytes.,EUROPEAN JOURNAL OF PHARMACOLOGY,2001 Jul,424(2):97-105
SCI論文 洪宏杰、(Loh SH)、(Yen MH)*,Suppression of the development of hypertension by the inhibitor of inducible nitric oxide synthase.,BRITISH JOURNAL OF PHARMACOLOGY,2000 Oct,131(3):631-637
 
研討會論文/Conference Papers
(發表主題或論文名稱,研討會名稱,演講地點,研討會期間,受邀演講題目)
1﹒ The Computational Pharmaceutical Analysis Study of Rehmanniae Radix etRhizma Extrato treat Alzheimer's Disease,The 17th Biophysics Conference,Institute of BioMedical Sciences, Academia Sinica,2012.5.23 ~ 2012.5.25,
2﹒ Study the effects of tanshinone ⅡA on angiotensin Ⅱ-induced rat thoracic aortic vascular smooth muscle cell proliferation,第27屆生物醫學聯合學術年會,國防醫學院,2012.3.17 ~ 2012.3.18,
3﹒ Virtual Screening and QSAR analysis for Mitogen-activatedprotein kinase kinase 1 (MEK1) inhibitors,2011台灣酵素機制研討會,國立中興大學,2011.12.15 ~ 2011.12.16,
4﹒ Chinese herbs on smooth musle cell proliferation : molecular mechanism approach.,血管生物研究與進展國際研討會(International Symposium on Vascular Biology 2007),台灣 台中 中國醫藥大學,2007.1.13 ~ 2007.1.13,
5﹒ Modulation of the stress signal-pathway and reactive oxygen species generation by isosteviol in angiotensin II induced proliferation of rat aortic smooth muscle cells.,3rd Asia-Pacific Association of Medicine Congress-Heart Failure,台北,2006.10.27 ~ 2006.10.30,
6﹒ The anti-hypertrophic mechanism of isosteviol on endothelin-1 induced hypertensive damage of the failure cardiomyocytes.,3rd Asia-Pacific Association of Medicine Congress-Heart Failure,台北,2006.10.27 ~ 2006.10.30,
7﹒ 血管緊張素II在血管中經由氧化張力引起的訊息傳遞,2006國際華夏醫藥新技術新管理高峰論壇,山東煙台,2006.10.22 ~ 2006.10.25,
8﹒ Angiotensin II induces endothelin-1 Gene expression via Reactive Oxygen Species-sensitive Extracellular Signal-regulated Kinase Pathway in Rat Aortic,The 26Annual Scientific Meeting of the Japanese Society of Hyper,Miyazaki, Japan,2003.10.30 ~ 2003.11.1,
 
研究計畫/Research Grant
(研究類型,研究計畫代號,主持人,補助或委託單位名稱,計畫名稱,研究經費,計畫期間)
1﹒ 個別型,CCMP99-RD-047,高尚德(Shung-Te Kao),唐娜櫻(Nou-Ying Tang)、李德茂(Te-Mao Li)、洪宏杰(Hong, Hong-Jye),衛福部,建立國外大學中醫學系畢業生學歷甄試及國內實習制度之研究,$790000,2010.12.29 ~ 2011.12.28
2﹒ 個別型,CMU99-TC-06,洪宏杰(Hong, Hong-Jye),本校(含附醫),丹參酮抑制血管張力素所誘導大鼠心臟成纖維細胞之增生,$190000,2010.9.1 ~ 2011.3.31
3﹒ 個別型,CMU96-082,洪宏杰,本校(含附醫),銀杏萃取物於平滑肌細胞對血管收縮素所誘發內皮素基因表現的作用,$280000,2007.8.1 ~ 2008.7.31
4﹒ 個別型,NSC 95-2320-B-039-039-,洪宏杰,鄭志鴻、黃家樂(Kar-Lok Wong),科技部,Puerarin於血管平滑肌細胞對血管收縮素所誘發內皮素基因表現的作用,$860000,2006.8.1 ~ 2007.7.31
5﹒ 個別型,NSC 94-2320-B-039 -030,洪宏杰(Hong,Hong-Jye),(鄭志鴻),科技部,Trilinolein於平滑肌細胞對血管收縮素所誘發內皮素基因表現的作用,$961000,2005.8.1 ~ 2006.7.31
6﹒ 個別型,NSC 93-2320-B-039-050,洪宏杰(Hong,Hong-Jye),科技部,Baicalein於平滑肌細胞對血管收縮素所誘發內皮素基因表現的作用,$920000,2004.8.1 ~ 2005.7.31
7﹒ 個別型,CMU93-CM-18,洪宏杰(Hong,Hong-Jye),08,川芎生物鹼tetramethylpyrazine於平滑肌細胞對血管收縮素所誘發內皮素基因表現的作用,$150000,2004.8.1 ~ 2005.7.31
8﹒ 個別型,CMU92-CM-07,洪宏杰(Hong,Hong-Jye),蘇奕彰(Su,Yi-Chang),本校(含附醫),探討內毒素刺激臍帶內皮細胞產生Monocyte chemoattractant protein-1過程中的相關分子機轉,$200000,2003.8.1 ~ 2004.7.31
9﹒ 個別型,NSC92-2320-B-039-044-,洪宏杰(Hong,Hong-Jye),科技部,中醫清熱涼血法對自發性高血壓大鼠的作用及其相關機轉之研究,$670000,2003.8.1 ~ 2004.7.31
10﹒ 個別型,CCMP92-RD-005,洪宏杰(Hong,Hong-Jye),蘇奕彰(Su,Yi-Chang),衛福部,併用黃耆萃取物對propranolol降血壓作用的影響,$600000,2003.1.23 ~ 2003.12.31