學術研究成果/Publication
基本資料/Profiles
姓名/Name: 柯承志 性別/Gender:
英文姓名/
English Name:
Cherng-Jyh Ke 英文縮寫/
Abbreviation:
任職單位/
Affiliation:
1.通識教育中心(兼任助理教授) / General Education Center (Part-Time Assistant Professor)
2.中國附醫醫研部生醫材料創業研究發展中心(助理研究員) / Biomaterials Translational Research Center (Assistant Research Fellow)
Email: fonchanwd@gmail.com
研究專長/Fields of Specialty
1﹒ Biomaterials & Bioconjugation
2﹒ Drug Delivery System
3﹒ Nanotechnology
4﹒ Regeneration Medicine & Tissue Engineering
5﹒ hMSC for Regeneration Medicine
6﹒ Multifunction Drug Carrier
7﹒ Inorganic Nanoparticle
 
期刊論文/Journal Paper
(作者群,論文題目,期刊名稱,出版年月,卷號(期別):頁次起迄)
SCI論文 柯承志(Cherng-Jyh Ke)、(Kuo-Hui Chiu)、(Ching-Yun Chen)、(Chiung-Hua Huang)*、姚俊旭(Chun-Hsu Yao)*,Alginate-gelatin based core-shell capsule enhances the osteogenic potential of human osteoblast-like MG-63 cells,MATERIALS & DESIGN,2021 Sep,210():110109-110119
SCI論文 (Wei-Yao Chen)、(Yu-Ting Chen)、柯承志(Cherng-Jyh Ke)、(Ching-Yun Chen)、(Feng-Huei Lin)*,The Synthesis and Evaluation of RGD-Conjugated Chitosan Gel as Daily Supplement for Body Weight Control,Materials,2021 Aug,14(16):4467
SCI論文 (Chung-Kai Sun)、柯承志(Cherng-Jyh Ke)、(Yi-Wen Lin)、林峯輝(Feng-Huei Lin)、(Tung-Hu Tsai)*、孫瑞昇(Sun, Jui-Sheng)*,Transglutaminase Cross-Linked Gelatin-Alginate-Antibacterial Hydrogel as the Drug Delivery-Coatings for Implant-Related Infections,Polymers,2021 Feb,13(3):414
SCI論文 (Ching-Yun Chen)、(Chunching Li)、柯承志(Cherng-Jyh Ke)、孫瑞昇(Sun, Jui-Sheng)*、林峯輝(Lin, Feng-Huei)*,Kartogenin Enhances Chondrogenic Differentiation of MSCs in 3D Tri-Copolymer Scaffolds and the Self-Designed Bioreactor System,Biomolecules,2021 Jan,11(115):
SCI論文 (Chiung-Hua Huang)、(Ting-Ju Chuang)、柯承志(Cherng-Jyh Ke)*、姚俊旭(Chun-Hsu Yao)*,Doxorubicin-Gelatin/Fe3O4-Alginate Dual-Layer Magnetic Nanoparticles as Targeted Anticancer Drug Delivery Vehicles,Polymers,2020 Aug,12(8):
SCI論文 (Yi-Wen Lin)、(Chih-Hsiang Fang)、(Fan-Qi Meng)、柯承志(Cherng-Jyh Ke)*、(Feng-Huei Lin)*,Hyaluronic Acid Loaded with Cerium Oxide Nanoparticles as Antioxidant in Hydrogen Peroxide Induced Chondrocytes injury: An In Vitro Osteoarthritis Model,MOLECULES,2020 Aug,25(19):4407-4421
SCI論文 (Chao-kai Hu)、柯承志(Cherng-Jyh Ke)、(Chung-yu Wu)*,Identification of biomarkers for early diagnosis of Parkinson’s disease by multi-omics joint analysis,SAUDI JOURNAL OF BIOLOGICAL SCIENCES,2020 Apr,27():2082-2088
SCI論文 (Wei-Ting Kuo)、(Jian-Yuan Huang)、(Min-Hua Chen)、(~)、柯承志(Cherng-Jyh Ke)、(Feng-Huei Lin)*,Development of gelatin nanoparticles conjugated with phytohemagglutinin erythroagglutinating loaded with gemcitabine for inducing apoptosis in non-small cell lung cancer cells,Journal of Materials Chemistry B,2016 Mar,():2444-2454
SCI論文 (Sheu, Shiow-Yunn)*、(Hong, Yi-Wen)、(Sun, Jui-Sheng)、(~)、柯承志(Cherng-Jyh Ke),Radix Scrophulariae extracts (harpagoside) suppresses hypoxia-induced microglial activation and neurotoxicity,BMC Complementary and Alternative Medicine,2015 Sep,15(324):
SCI論文 李漢忠(Han-Chung Lee)、徐媛曼(Yuan-Man Hsu)、蔡金川(Chin-Chuan Tsai)、柯承志(Cherng-Jyh Ke)、姚俊旭(Chun-Hsu Yao)、陳悅生(Yueh-Sheng Chen)*,Improved peripheral nerve regeneration in streptozotocin-induced diabetic rats by oral lumbrokinase,AMERICAN JOURNAL OF CHINESE MEDICINE,2015 May,43(2):215-230
SCI論文 (Ching-Yun Chen)、柯承志(Cherng-Jyh Ke)、(Ko-Chung Yen)、(Hui-Chen Hsieh)、(Jui-Sheng Sun)*、林峰輝*,3D Porous Calcium-Alginate Scaffolds Cell Culture System Improved Human Osteoblast Cell Clusters for Cell Therapy,Theranostics,2015 Mar,5(6):643-655
SCI論文 (Shiow-Yunn Sheu)、(Shin-Rong Ho)、(Jui-Sheng Sun)*、(Ching-Yun Chen)、柯承志(Cherng-Jyh Ke),Arthropod Steroid Hormone (20-Hydroxyecdysone) Suppresses IL-1 Beta-Induced Catabolic Gene Expression in Cartilage.,BMC Complementary and Alternative Medicine,2015 ,15(1):1-8
SCI論文 (Jimmy Kuan-Jung Li)、柯承志(Cherng-Jyh Ke)、(Chung-An J. Lin)、(Zhi-Hua Cai)、(Ching-Yun Chen)、(Walter H. Chang)*,Facile Method for Gold Nanocluster Synthesis and Fluorescence Control Using Toluene and Ultrasound,Journal of Medical and Biological Engineering,2013 ,33(1):23-28
SCI論文 柯承志(Cherng-Jyh Ke)、(Wei-Lun Chiang)、(Zi-Xian Liao)、(Hsin-Lung Chen)、(Ping-Shan Lai)、(Jui-Sheng Sun)*、(Hsing-Wen Sung)*,Real Time Visualization of pH-responsive PLGA Hollow Particles Containing a Gas-generating Agent Targeted for Acidic Organelles for Overcoming Multi-drug Resistance,BIOMATERIALS,2013 ,34():1-10
SCI論文 柯承志(Cherng-Jyh Ke)、(Yi-Jou Lin)、(Yi-Chen Hu)、(Wei-Lun Chiang)、(Ko-Jie Chen)、(Wen-Cheng Yang)、(Hao-Li Liu)、(Chien-Chung Fu)*、(Hsing-Wen Sung)*,Multidrug Release Based on Microneedle Arrays Filled with pH-responsive PLGA Hollow Microspheres,BIOMATERIALS,2012 ,20():5156-5165
SCI論文 (Wei-Lun Chiang)、柯承志(Cherng-Jyh Ke)、(Zi-Xian Liao)、(San-Yuan Chen)、(Fu-Rong Chen)、(Chun-Ying Tsai)、(Younan Xia)*、(Hsing-Wen Sung)*,Pulsatile Drug Release from PLGA Hollow Microspheres by Controlling the Wall’s Permeability with a Magnetic Field,Small,2012 ,8(2):3584-3588
SCI論文 (Po-Wei Lee)、(Sheng-Hsiang Hsu)、(Jin-Sheng Tsai)、(Fu-Rong Chen)、(Pei-Jai Huang)、柯承志(Cherng-Jyh Ke)、(Zi-Xian Liao)、(Chun-Wen Hsiao)、(Hao-Jan Lin)、(Hsing-Wen Sung)*,Multifunctional Core-shell Polymeric Nanoparticles for Transdermal DNA Delivery and Epidermal Langerhans cells Tracking,BIOMATERIALS,2010 ,31():2425-2434
 
研討會論文/Conference Papers
(發表主題或論文名稱,研討會名稱,演講地點,研討會期間,受邀演講題目)
1﹒ Study of Adipose-derived Stem Cells Encapsulated with 3D Culture Microenvironment in Soft Tissue Reconstruction,TERMIS-AP + ABMC7 2019 Congress,Brisbane Convention&Exhibition Centre, Australia,2019.10.14 ~ 2019.10.17,
2﹒ Multiple Encapsulation System for Breast Cancer Therapy,TERMIS-AMBC7 2019,Brisbane Convention&Exhibition Centre, Australia,2019.10.14 ~ 2019.10.17,
3﹒ The Bone Differentiation Effect of Adipose-derived Stem Cell (ADSCs) in Alginate-Gelatin Cell Capsules (AGC),TERMIS-AP + ABMC7 2019,Brisbane Convention&Exhibition Centre, Australia,2019.10.14 ~ 2019.10.17,
4﹒ Apply Newly Developed multilayer capsules on Dentin Pore filled,2019 Joint Conference on Biotechnology of China Medical University and Asia University,Taiwan,2019.5.24 ~ 2019.5.24,
5﹒ Study of Adipose-derived Stem Cells Encapsulated with 3D Culture Microenvironmentin Soft Tissue Reconstruction,2019 Joint Conference on Biotechnology of China Medical University and Asia University,Taiwan,2019.5.24 ~ 2019.5.24,
6﹒ The Bone Differentiation Effect of Adipose-derived Stem Cells (ADSCs) in Alginate-Gelatin Cell Capsules (AGC),2019 Joint Conference on Biotechnology of China Medical University and Asia University,Taiwan,2019.5.24 ~ 2019.5.24,
7﹒ Growth Factor Rich Membrane as Cell-laden Scaffold for Bone Regeneration,2019 Joint Conference on Biotechnology of China Medical University and Asia University,Taiwan,2019.5.24 ~ 2019.5.24,
8﹒ High-throughput Generation of Alginate/Gelatin Hydrogel Cell Capsules for Long-term Culture,2019 International Advanced Drug Delivery Symposium & Annual Meeting of Biomaterials and Controlled Releases Society in Taiwan,Department of Biomedical Engineering and Environmental Science, National Tsing Hua University, Hsinc,2019.3.28 ~ 2019.3.29,
9﹒ Apply Newly Developed multilayer capsules on Dentin Pore filled,2019 International Advanced Drug Delivery Symposium & Annual Meeting of Biomaterials and Controlled Releases Society in Taiwan,Department of Biomedical Engineering and Environmental Science, National Tsing Hua University, Hsinc,2019.3.28 ~ 2019.3.29,
10﹒ Growth Factor Rich Membrane as Cell-laden Scaffold for Bone Regeneration,2019 International Advanced Drug Delivery Symposium & Annual Meeting of Biomaterials and Controlled Releases Society in Taiwan,Department of Biomedical Engineering and Environmental Science, National Tsing Hua University, Hsinc,2019.3.28 ~ 2019.3.29,
11﹒ ,YUCOMAT2018,Hunguest Hotel Sun Resort,Herceg Novi, Montenegro,2018.9.3 ~ 2018.9.7,High Throughput Generation of Alginate-Gelatin Capsules for Human Osteoblask-like Cells (MG63) long-term cultivation
12﹒ A Novel Multilayer Capsule as Desensitizing Agent for Dental Hypersensitivity,YUCOMAT 2018,蒙特內哥羅,2018.9.3 ~ 2018.9.7,
 
研究計畫/Research Grant
(研究類型,研究計畫代號,主持人,補助或委託單位名稱,計畫名稱,研究經費,計畫期間)
1﹒ 個別型,MOST 108-2314-B-039-033-MY3,柯承志(Cherng-Jyh Ke),孫瑞昇、姚俊旭(Chun-Hsu Yao),科技部,攜帶氧化石墨烯之智慧型水膠於骨組織工程之研究,$1308000,2021.8.1 ~ 2022.7.31
2﹒ 產學合作,109426AL,柯承志(Cherng-Jyh Ke),共信醫藥科技股份有限公司,智慧型水膠於生醫應用上安全性與功能性驗證,$1543480,2021.1.15 ~ 2022.5.10
3﹒ 個別型,MOST 108-2314-B-039-033-MY3,柯承志(Cherng-Jyh Ke),孫瑞昇、姚俊旭(Chun-Hsu Yao),科技部,攜帶氧化石墨烯之智慧型水膠於骨組織工程之研究,$1308000,2020.8.1 ~ 2021.7.31
4﹒ 個別型,MOST 109-2314-B-567-002-,姜秉均,鄭劍廷、柯承志(Cherng-Jyh Ke),科技部,間質性膀胱炎/化學性膀胱炎與膀胱過動症新治療藥物的研發與應用-包裹肉毒桿菌素黏液附著型奈米級載體,$1150000,2020.8.1 ~ 2021.7.31
5﹒ 產學合作,10942617,柯承志(Cherng-Jyh Ke),禾祺銳生技股份有限公司,醫材體外細胞毒性試驗,$22826,2020.8.1 ~ 2020.12.31
6﹒ 學生參與計畫,CMU109-SR-11,柯承志(Cherng-Jyh Ke),本校(含附醫),新型生物墨水開發,$35000,2020.8.1 ~ 2021.2.28
7﹒ 學生參與計畫,109-2813-C-039-016-E,柯承志(Cherng-Jyh Ke),科技部,新型生物墨水開發,$48000,2020.7.1 ~ 2021.2.28
8﹒ 產學合作,108426DY,柯承志(Cherng-Jyh Ke),愛派司生技股份有限公司,醫材體外細胞毒性試驗,$34239,2020.6.1 ~ 2020.12.31
9﹒ 產學合作,108426CR,柯承志(Cherng-Jyh Ke),景華生技股份有限公司,新淨寶成分分析,$131826,2020.4.10 ~ 2020.10.31
10﹒ 產學合作,10842687,柯承志(Cherng-Jyh Ke),發覺國際有限公司,細胞載體安全性評估,$21000,2019.10.1 ~ 2020.6.30
11﹒ 個別型,MOST 108-2314-B-039-033-MY3,柯承志(Cherng-Jyh Ke),孫瑞昇、姚俊旭(Chun-Hsu Yao),科技部,攜帶氧化石墨烯之智慧型水膠於骨組織工程之研究,$1308000,2019.8.1 ~ 2020.7.31
12﹒ 學生參與計畫,CMU108-SR-18,柯承志(Cherng-Jyh Ke),本校(含附醫),攜帶脂肪幹細胞之載體於軟組織重建之研究,$35000,2019.8.1 ~ 2020.2.28
13﹒ 學生參與計畫,108-2813-C-039-018-E,柯承志(Cherng-Jyh Ke),科技部,攜帶脂肪幹細胞之載體於軟組織重建之研究,$48000,2019.7.1 ~ 2020.2.28
14﹒ 產學合作,107426CF,柯承志(Cherng-Jyh Ke),禾祺銳生技股份有限公司,材料物化性能力比對測試,$22826,2019.6.1 ~ 2019.12.31
15﹒ 產學合作,107426AV,柯承志(Cherng-Jyh Ke),諾提亞生技有限公司,氧化石墨烯水溶液體外細胞毒性試驗,$22826,2019.5.1 ~ 2019.12.31
16﹒ 個別型,MOST 107-2314-B-039-004-,柯承志(Cherng-Jyh Ke),科技部,智慧型水膠與多孔性骨釘結合於骨組織再生之應用,$700000,2018.8.1 ~ 2019.11.30
17﹒ 學生參與計畫,CMU107-SR-08,柯承志(Cherng-Jyh Ke),本校(含附醫),神奇磁性微球體應用於生長因子萃取系統之開發,$35000,2018.8.1 ~ 2019.2.28
18﹒ 產學合作,10742601,姚俊旭(Chun-Hsu Yao),柯承志(Cherng-Jyh Ke),德聯生醫科技有限公司,牛港刺(馬甲子)急性毒性篩選試驗及成分定性分析,$84000,2018.8.1 ~ 2018.11.30
19﹒ 產學合作,106426CC,柯承志(Cherng-Jyh Ke),姚俊旭(Chun-Hsu Yao),埃米生醫科技股份有限公司,奈米金屬抗菌劑體外細胞毒性試驗,$90000,2018.7.1 ~ 2018.9.30
20﹒ 學生參與計畫,107-2813-C-039-011-E,柯承志(Cherng-Jyh Ke),科技部,神奇磁性微球體應用於生長因子萃取系統之開發,$48000,2018.7.1 ~ 2019.2.28
21﹒ 產學合作,106426AY,姚俊旭(Chun-Hsu Yao),林?輝、柯承志(Cherng-Jyh Ke)、何建宜(Chien-Yi Ho),瑞德生物科技有限公司,探討雙相陶瓷人工骨替代物對不同骨缺損動物模式之骨融合機制,$315000,2018.1.1 ~ 2018.12.31
22﹒ 產學合作,10642629,柯承志(Ke, Cherng-Jyh),姚俊旭(Yao, Chun-Hsu),力煒奈米科技股份有限公司,奈米銀水溶液生物相容性評估,$202011,2017.9.1 ~ 2018.4.30
23﹒ 學生參與計畫,CMU106-SR-28,蔡育勳(Yuhsin Tsai),柯承志(Cherng-Jyh Ke),本校(含附醫),急性梗塞後的心衰竭治療模式之建立 - 以超音波進行藥物釋放與影像追蹤之技術,$35000,2017.8.1 ~ 2018.2.28
24﹒ 學生參與計畫,CMU106-SR-29,蔡育勳(Yuhsin Tsai),柯承志(Cherng-Jyh Ke),本校(含附醫),穀胱甘肽對於LPS誘發SW1353細胞發炎反應的抑制能力探討,$35000,2017.8.1 ~ 2018.2.28
25﹒ 產學合作,10642612,柯承志(Ke, Cherng-Jyh),陳冬生(Chen, Tung-Sheng),海昌生化科技股份有限公司,膠原蛋白及生物薄膜DNA分析,$79891,2017.8.1 ~ 2018.7.30
26﹒ 學生參與計畫,CMU106-SR-15,柯承志(Ke, Cherng-Jyh),本校(含附醫),交聯劑的來源對於神經導管之影響:分別以化合物(bis(vinylsulfonyl)methane, BVSM) 及蛋白酶(transglutaminase, TGase)作為交聯劑之探討,$35000,2017.8.1 ~ 2018.2.28
27﹒ 學生參與計畫,106-2813-C-039-029-B,蔡育勳(Yuhsin Tsai),柯承志(Cherng-Jyh Ke),科技部,穀胱甘肽對於LPS誘發SW1353細胞發炎反應的抑制能力探討,$48000,2017.7.1 ~ 2018.2.28
28﹒ 學生參與計畫,106-2813-C-039-028-B,蔡育勳(Yuhsin Tsai),柯承志(Cherng-Jyh Ke),科技部,急性梗塞後的心衰竭治療模式之建立 - 以超音波進行藥物釋放與影像追蹤之技術,$48000,2017.7.1 ~ 2018.2.28
29﹒ 產學合作,105426EA,柯承志(Ke, Cherng-Jyh),璉璐健康科技有限公司,自性.記憶讚重複劑量口服投予安全性試驗,$80000,2017.7.1 ~ 2017.12.31
30﹒ 產學合作,10542683,柯承志(Ke, Cherng-Jyh),鐿騏興業有限公司,醫材體外細胞毒性試驗,$68478,2017.7.1 ~ 2017.10.31
31﹒ 學生參與計畫,106-2813-C-039-015-E,柯承志(Ke, Cherng-Jyh),科技部,交聯劑的來源對於神經導管之影響:分別以化合物(bis(vinylsulfonyl)methane, BVSM) 及蛋白酶(transglutaminase, TGase)作為交聯劑之探討,$48000,2017.7.1 ~ 2018.2.28
32﹒ 個別型,CMU105-TC-02,梁馨月(Hsin-Yueh Liang),陳悅生(Yueh-Sheng Chen)、柯承志(Cherng-Jyh Ke),本校(含附醫),超音波可控式多功能載體開發,$250000,2016.10.19 ~ 2017.7.31
33﹒ 個別型,MOST 105-2314-B-002 -195 -MY3,孫瑞昇(Jui-Sheng Sun),柯承志(Cherng-Jyh Ke),科技部,利用三維動態系統培養類應骨組織團塊應用於骨組織工程,$3975000,2016.8.1 ~ 2019.7.31
34﹒ 個別型,DMR-106-152,柯承志(Cherng-Jyh Ke),孫瑞昇、蔡佩宜,附醫院內計畫,新型內固定多孔性骨釘系統II (結合富含血小板的纖維蛋白),$200000,2016.8.1 ~ 2017.7.31
35﹒ 個別型,DMR-104-110,柯承志(Cherng-Jyh Ke),陳悅生(Yueh-Sheng Chen)、孫瑞昇(Jui-Sheng Sun),附醫院內計畫,可大量製備的褐藻酸-明膠/KGN膠囊應用於人類臍帶(Wharton`s Jelly)間葉幹細胞攜帶及軟骨分化之研究,$200000,2015.2.1 ~ 2015.12.31
 
專利/Patent
(專利名稱,專利類別,專利國別,專利號碼,專利期間)
1﹒ 促進骨再生的生物支架、其用途及其製備方法,發明專利,台灣,發明第I723615號,2021.4.1 ~ 2039.11.3
2﹒ 促進骨再生的生物支架、其用途及其製備方法,發明專利,台灣,I723615,2021.4.1 ~ 2039.11.3
3﹒ 用於製備富含血小板血漿及富含血小板纖維蛋白之裝置及套組,新型專利,台灣,M605103,2020.12.11 ~ 2028.5.24
4﹒ 白藜蘆醇之應用,發明專利,台灣,I652057,2019.3.1 ~ 2037.6.29
5﹒ 骨折內固定物件、製造彼之方法、以及包含該物件之套組,發明專利,台灣,I630005,2018.7.21 ~ 2036.9.6
6﹒ 一種促進間質幹細胞分化的套組與方法,發明專利,台灣,I522468,2016.2.21 ~ 2034.11.19
 
獲獎/Award
(獲獎名稱,給獎單位,獲獎日期)
1﹒ 107年度法人鏈結產學合作成果發表會 - 績優案源獎,科技部,2018.11.28