Welcome

We focus on understanding the cellular and molecular biological mechanisms underlying neurological diseases, with a specific emphasis on Sigma-1R, a versatile chaperone protein implicated in numerous neurodegenerative conditions. Our ongoing laboratory projects encompass two main areas: (I) exploring the molecular mechanisms and functions of Sigma-1R in the nuclear pore and nuclear envelope in neurodegenerative diseases, and (II) developing a screening platform for Sigma-1R agonists or antagonists with translational applications. Ultimately, we posit that Sigma-1R could serve as a promising pharmacological target for mitigating neurological diseases. In addition, our research delves into C9orf72 amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD), a prominent genetic contributor to familial ALS, as well as its presence in sporadic cases. Specifically, we investigate dipeptide repeat protein (DPR), particularly the arginine-rich DPR, which increases motor neuron death and promotes neuroinflammation. The project outlines three primary objectives: I) examining whether Sigma-1R can safeguard against motor neuron death in C9orf72 ALS/FTD by promoting nucleocytoplasmic transport function, II) assessing whether Sigma-1R can alleviate DPR-induced neuroinflammation by inhibiting glial activation, and III) establishing in vitro and in vivo models for DPR-induced C9orf72 ALS/FTD.

醫學院生物醫學研究所助理教授／Graduate Institute of Biomedical Sciences Assistant Professor

基本資料/Profiles

姓名：王紹銘／Wang, Shao-Ming
任職單位：醫學院生物醫學研究所助理教授
Graduate Institute of Biomedical Sciences Assistant Professor
電話：04-22053366 分機1758
E-mail：wangs@mail.cmu.edu.tw
ORCID：https://orcid.org/0000-0003-1479-9100
Google Scholar個人學術檔案

學歷/Education

國立成功大學基礎醫學研究所博士
National Cheng Kung University The Institute of Basic Medical Sciences PhD
中山醫學大學應用化學碩士班碩士
Chung Shan Medical University Department of Medical Applied Chemistry Master

經歷/Work experience

中國醫藥大學生物醫學研究所助理教授(1101101~)
China Medical University Graduate Institute of Biomedical Sciences Assistant Professor
National Institutes of Health (NIH)/National Institute on Drug Abuse (NIDA) Research Scholar(1071022~1101021)

主管經歷/Administrative experience

專長/Research expertise